Toward the racemic total synthesis of hederacines A and B: construction of an advanced tricyclic intermediate.
Toward the racemic total synthesis of hederacines A and B: construction of an advanced tricyclic intermediate.
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DOI：
10.1021/ol2004353
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发表时间：
2011-04
期刊：
影响因子：
5.2
通讯作者：
M. Yamashita;Tetsuya Yamashita;S. Aoyagi
中科院分区：
文献类型：
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作者：
M. Yamashita;Tetsuya Yamashita;S. Aoyagi
介绍了常春藤皂苷A和B的全合成研究进展。我们的方法包括烯丙基氰酸酯到异氰酸酯重排，烯炔闭环复分解，和C-5氨基和全氢甘菊环[5，6-B]呋喃酮中间体的C-12位之间的跨环反应。
Progress toward the total synthesis of hederacines A and B is described. Our approach involves an allylic cyanate-to-isocyanate rearrangement, eneyne ring-closing metathesis, and a transannular reaction between the C-5 amino group and the C-12 position of the perhydroazuleno[5,6-b]furanone intermediate.