Taste sensitivity to 6-n-propylthiouracil is associated with endocannabinoid plasma levels in normal-weight individuals
Taste sensitivity to 6-n-propylthiouracil is associated with endocannabinoid plasma levels in normal-weight individuals
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DOI：
10.1016/j.nut.2012.09.018
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发表时间：
2013-03-01
期刊：
影响因子：
4.4
通讯作者：
Banni, Sebastiano
中科院分区：
文献类型：
--
作者：
Barbarossa, Iole Tomassini;Carta, Gianfranca;Banni, Sebastiano
目的：对6-n-丙基硫脲嘧啶（PROP）的敏感性降低已被证明与能量摄入增加有关，从而增加了体重指数，尽管其他研究尚未证实这种关联，表明涉及其他因素。我们研究了内源性大麻素系统，它也调节饥饿/饱腹感和能量平衡，是否在调节受PROP敏感性影响的饮食行为中发挥作用。方法：测定正常体重PROP超味觉者（STs）和PROP非味觉者（nt）血浆内源性大麻素2-花生四烯醇甘油（2-AG）、anandamide （AEA）及其同系物棕榈酰乙醇酰胺和油基乙醇酰胺（OEA）的含量。认知饮食行为障碍通过三因素饮食问卷进行评估，该问卷评估饮食限制、解除抑制和感知饥饿。结果：NTs组的去抑制评分高于STs组（P = 0.02）。此外，在nt中，OEA与感知饥饿得分呈负相关（r = -0.7, P = 0.002）， AEA与约束得分呈正相关（r = 0.5, P = 0.04），与感知饥饿得分呈负相关（r = -0.47, P = 0.05），尽管后者的相关性在统计学意义的极限（r = -0.47, P = 0.05）。此外，我们发现NT组血浆中AEA和2-AG的浓度低于ST组（AEA, P = 0.034; 2-AG, P = 0.003）。结论：我们的数据表明，在正常体重的受试者中，NTs中较高的去抑制行为可能部分补偿了外周内源性大麻素的减少，从而下调了饥饿-能量摄入回路。(C) 2013爱思唯尔公司版权所有。
Objective: A decreased sensitivity to 6-n-propylthiouracil (PROP) has been shown to be associated with increased energy intake and therefore an increased body mass index, although other studies have not confirmed this association, suggesting the involvement of other factors. We investigated whether the endocannabinoid system, which also modulates hunger/satiety and energy balance, plays a role in modulating eating behavior influenced by a sensitivity to PROP.Methods: The plasma profile of the endocannabinoids 2-arachidonoylglycerol (2-AG), anandamide (AEA), and congeners of AEA, palmitoylethanolamide and oleylethanolamide (OEA), was determined in normal-weight PROP supertasters (STs) and PROP non-tasters (NTs). A cognitive eating behavior disorder was assessed by the Three-Factor Eating Questionnaire, which estimates dietary restraint, disinhibition, and perceived hunger.Results: The disinhibition score of NTs was higher than those of STs (P = 0.02). Moreover, in NTs, OEA was inversely correlated to the perceived hunger score (r = -0.7, P = 0.002), and AEA was positively correlated to the restraint score (r = 0.5, P = 0.04) and negatively to the perceived hunger score, although the latter correlation was at the limit of statistical significance (r = -0.47, P = 0.05). In addition, we found lower concentrations of AEA and 2-AG in the plasma of NT compared with ST subjects (AEA, P = 0.034; 2-AG, P = 0.003).Conclusions: Our data suggest that a higher disinhibition behavior in NTs may be compensated in part, in normal-weight subjects, by the decrease of peripheral endocannabinoids to downregulate the hunger-energy intake circuitry. (C) 2013 Elsevier Inc. All rights reserved.