Women who smoke like men die like men who smoke: findings from two Australian cohort studies
Women who smoke like men die like men who smoke: findings from two Australian cohort studies
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DOI：
10.1136/tc.2010.039172
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发表时间：
2011-07-01
期刊：
影响因子：
5.2
通讯作者：
Dobson, Annette
中科院分区：
文献类型：
--
作者：
Jamrozik, Konrad;McLaughlin, Deirdre;Dobson, Annette
研究背景吸烟史相似的男性和女性是否有相似的吸烟相关疾病的发病率和死亡率存在争议。目的比较男性和女性吸烟者（按吸烟数量分类）和已戒烟者（按戒烟时间分类）的所有死因和各种吸烟相关原因的死亡率。方法对10年的吸烟史男性和女性吸烟者（按吸烟数量分类）和已戒烟者（按戒烟时间分类）的所有死因和各种吸烟相关原因的死亡率进行比较。根据国家死亡指数确定的死亡人数进行研究。研究背景是1996年在澳大利亚开展的两项队列研究。受试者为：男性（n = 12 154）和女性（n = 11 707），招募时年龄（平均值（SD））分别为72.1（4.4）和72.5（1.5）岁。主要的结果测量是男性和女性分别的HR和使用比例风险模型的组合分析计算的RR（所有原因造成的死亡）和竞争风险比例风险模型结果男性所有原因死亡的HR吸烟者（n = 3549例死亡）和女性（n = 2665例死亡）的死亡率随吸烟量增加而增加，而戒烟者的死亡率随戒烟后的时间减少。在不同的吸烟相关疾病组中也发现了类似的效应，其中肺癌和慢性阻塞性肺病的剂量反应效应最大。女性相对于男性的HR的比例接近团结和95% CI包括团结几乎所有的comparation.Conclusions的数据提供了有力的证据，男性和女性具有相似的吸烟模式的经验，由于吸烟的死亡率相似。
Background There is controversy about whether men and women with similar smoking histories have similar incidence and mortality rates from smoking related diseases.Objective To compare mortality rates from all causes of death and various smoking related causes for men and women smokers categorised by numbers of cigarettes smoked and for ex-smokers by time since quitting.Methods This was a 10-year follow-up study with deaths identified from the National Death Index. The setting was two cohort studies in Australia established in 1996. Participants were: men (n = 12 154) and women (n = 11 707) aged (mean (SD)) 72.1 (4.4) and 72.5 (1.5) years, respectively, when recruited. The main outcome measure was HRs for men and women separately and RRs calculated from combined analyses using proportional hazards models (for deaths from all causes) and competing risks proportional hazards models (for specific causes).Results HRs for deaths from all causes for men (n = 3549 deaths) and women (n = 2665 deaths) among smokers increased with amount smoked and for ex-smokers decreased with time since quitting. Similar effects were found for various groups of smoking-related conditions with the dose-response effects largest for lung cancer and chronic obstructive pulmonary disease. The ratios of HRs for women relative to men were near unity and the 95% CIs included unity for almost all comparisons.Conclusions The data provide strong evidence that men and women with similar patterns of smoking experience similar rates of death due to smoking.