Response inhibition and impulsivity: an fMRI study
Response inhibition and impulsivity: an fMRI study
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DOI：
10.1016/s0028-3932(03)00077-0
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发表时间：
2003-01-01
期刊：
影响因子：
2.6
通讯作者：
Woodruff, PWR
中科院分区：
文献类型：
--
作者：
Horn, NR;Dolan, M;Woodruff, PWR
攻击性、自杀和暴力行为与冲动的个性和难以抑制反应有关。我们使用全脑功能磁共振成像（fMRI）检查19名正常受试者在执行Go/NoGo任务时反应抑制的神经相关性。受试者完成艾森克冲动量表、巴拉特冲动量表（BIS）和行为冲动任务。研究了血氧水平依赖性反应、特质冲动性、任务绩效与全国成人阅读测验智商之间的关系。反应抑制过程中的神经反应在右侧眶额皮质最为突出。反应也见于上级颞回、内侧眶额皮质、扣带回和顶下小叶，主要在右侧。受试者的冲动性量表得分较高，谁犯了更多的错误，有更大的激活边缘区在反应抑制，而较少的冲动和那些最少的错误激活高阶关联区。探索性因素分析的轨道激活，个性措施和错误的委员会没有发现一个单一的维度冲动。然而，后眶激活和Eysenck的冲动分数之间的强关联的一个单一的因素表明，更大的参与右眶额皮质需要保持冲动的个人行为抑制。低智商比冲动分数更重要，在确定错误的任务期间的委员会。在Go/NoGo任务期间的脑活动的神经成像可能有助于理解功能性神经解剖学和反应抑制的相关神经化学。它还可以允许研究生理和心理干预对反社会人格障碍等临床条件下的反应抑制的影响。(C)2003爱思唯尔有限公司。保留所有权利。
Aggressive, suicidal and violent behaviour have been associated with impulsive personality and difficulty in inhibiting responses. We used functional magnetic resonance imaging (fMRI) of the whole brain to examine the neural correlates of response inhibition in 19 normal subjects as they performed a Go/NoGo task. Subjects completed Eysenck's Impulsivity Scale, Barratt's Impulsivity Scale (BIS) and behavioural impulsivity tasks. Associations between blood oxygen level dependent (BOLD) response, trait impulsivity, task performance and National Adult Reading Test (NART) IQ were investigated. Neural response during response inhibition was most prominent in the right lateral orbitofrontal cortex. Responses were also seen in superior temporal gyrus, medial orbitofrontal cortex, cingulate gyrus, and inferior parietal lobule, predominantly on the right side. Subjects with greater scores on impulsivity scales and who made more errors had greater activation of paralimbic areas during response inhibition, while less impulsive individuals and those with least errors activated higher order association areas. Exploratory factor analysis of orbital activations, personality measures and errors of commission did not reveal a unitary dimension of impulsivity. However, the strong association between posterior orbital activation and Eysenck's impulsivity score on a single factor suggests that greater engagement of right orbitofrontal cortex was needed to maintain behavioural inhibition in impulsive individuals. Lower IQ was more important than impulsivity scores in determining errors of commission during the task. Neuroimaging of brain activity during the Go/NoGo task may be useful in understanding the functional neuroanatomy and associated neurochemistry of response inhibition. It may also allow study of the effects of physical and psychological interventions on response inhibition in clinical conditions such as antisocial personality disorder. (C) 2003 Elsevier Ltd. All rights reserved.