Chronic Obstructive Pulmonary Disease: CT Quantification of Airways Disease
Chronic Obstructive Pulmonary Disease: CT Quantification of Airways Disease
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DOI：
10.1148/radiol.12111270
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发表时间：
2012-10-01
期刊：
影响因子：
19.7
通讯作者：
Gevenois, Pierre Alain
中科院分区：
文献类型：
--
作者：
Hackx, Maxime;Bankier, Alexander A.;Gevenois, Pierre Alain
慢性阻塞性肺疾病（COPD）是世界范围内发病率和死亡率不断增加的原因，并导致巨大的社会和经济负担。COPD是一种具有肺外和肺成分的异质性疾病。肺部部分的特征是气流受限，不完全可逆。作者认为，目前可用的将气流限制测量与临床参数相结合的分类都不足以确定特定COPD患者的预后和治疗。关于气流限制的原因，CT可用于量化COPD的两个主要贡献：肺气肿和小气道疾病（气道狭窄）。CT定量以及随后的COPD表型分析有助于改善患者护理、评估COPD进展和识别死亡风险增加的重度COPD。小气道疾病可以通过反映形态学的测量、阻塞的量化和气道壁的变化来量化。本文详细介绍了这三种方法，并总结了进一步研究的前景和方向。(C)RSNA，2012年
Chronic obstructive pulmonary disease (COPD) is an increasing cause of morbidity and mortality worldwide and results in substantial social and economic burdens. COPD is a heterogeneous disease with both extrapulmonary and pulmonary components. The pulmonary component is characterized by an airflow limitation that is not fully reversible. In the authors' opinion, none of the currently available classifications combining airflow limitation measurements with clinical parameters is sufficient to determine the prognosis and treatment of a particular patient with COPD. With regard to the causes of airflow limitation, CT can be used to quantify the two main contributions to COPD: emphysema, and small airways disease (a narrowing of the airways). CT quantification-with subsequent COPD phenotyping-can contribute to improved patient care, assessment of COPD progression, and identification of severe COPD with increasing risk of mortality. Small airways disease can be quantified through measurements reflecting morphology, quantification of obstruction, and changes in airways walls. This article details these three approaches and concludes with perspectives and directions for further research. (C) RSNA, 2012