The effect of nutritional support on weight gain of HIV-infected children with prolonged diarrhoea.
The effect of nutritional support on weight gain of HIV-infected children with prolonged diarrhoea.
复制标题
营养支持对长期腹泻的艾滋病毒感染儿童体重增加的影响。
DOI：
10.1111/j.1651-2227.2006.00013.x
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
Bennish,ML
中科院分区：
文献类型：
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作者：
Rollins,NC;vandenBroeck,J;Kindra,G;Pent,M;Kasambira,T;Bennish,ML
目的：探讨增加热量和蛋白质供给对HIV感染者迁延性腹泻患儿生长发育和免疫功能的影响。方法：将169例6~36个月、腹泻持续7天以上的HIV感染者随机分为两组，一组为迁延性腹泻患儿提供标准营养支持，另一组为住院至出院后继续强化饮食。结果：在注册至第8周至第8周期间，接受强化营养的儿童的体重增加(p<；0.001)显著高于接受标准饮食的儿童(按年龄计算的体重标准差分数的中位数增加+1.02vs.+0.01)。8周后，两组患者的中位体重速度均正常，且相似。两组患者的CD4细胞计数中值变化相似。两组的26周死亡率都很高(标准支持：22%，加强支持：29%)。结论：晚期HIV感染和长期腹泻儿童的营养支持导致显著和持续的体重增加，但不能改善CD4计数或生存。这些结果支持对感染艾滋病毒的儿童进行综合营养干预。
Aim: To examine the effect on growth and immunity of enhanced calorie and protein provision to HIV‐infected children presenting with prolonged diarrhoea.Methods: A total of 169 HIV‐infected children aged 6–36 months with diarrhoea for 7 days or more were randomly assigned to either standard nutrition support for children with prolonged diarrhoea or an enhanced diet started during hospitalisation and continued after discharge. The change in weight between enrolment and 8, 14 and 26 weeks and changes in plasma HIV‐RNA and CD4 cell count at 8 and 26 weeks were estimated.Results: Children receiving enhanced nutrition achieved significantly more weight gain (p < 0.001) between enrolment and 8 weeks than children on the standard diet (median increase in weight‐for‐age standard deviation score +1.02 vs. +0.01). After 8 weeks median weight velocity was normal and similar in both groups. The change in median CD4 count was similar in both groups. The 26‐week mortality rate was high in both groups (standard support: 22%, enhanced support: 29%).Conclusions: Nutrition support of children with advanced HIV infection and prolonged diarrhoea resulted in significant and sustained weight gain, but did not improve CD4 counts or survival. These results support integrated nutrition interventions for HIV‐infected children.