Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: a potential novel treatment in a rat model of Huntington's disease
Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: a potential novel treatment in a rat model of Huntington's disease
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DOI：
10.1016/s0006-8993(97)01428-5
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发表时间：
1998-03-16
期刊：
影响因子：
2.9
通讯作者：
Weiner, I
中科院分区：
文献类型：
--
作者：
Joel, D;Ayalon, L;Weiner, I
双侧电解苍白球损伤改善了双侧喹啉酸（QA）损伤对纹状体对术后体重、活动水平和水迷宫任务表现的有害影响，并减少了纹状体损伤的程度。鉴于 QA 纹状体损伤的神经退行性和行为影响被认为与亨廷顿舞蹈病中所见的影响相似，这些结果可能为这种疾病提供了一种潜在的新疗法。 (C) 1998 Elsevier Science B.V.
Bilateral electrolytic pallidal lesion ameliorated the deleterious effects of bilateral quinolinic acid (QA) lesion to the striatum on post-surgery weight, activity level, and performance in a water maze task, and reduced the extent of striatal damage. Given that the neurodegenerative and behavioral effects of QA striatal lesion are thought to mimic those seen in Huntington's disease, these results may point to a potential novel treatment for this disease. (C) 1998 Elsevier Science B.V.