Cytologic and DNA-cytometric very early diagnosis of oral cancer
Cytologic and DNA-cytometric very early diagnosis of oral cancer
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DOI：
10.1111/j.1600-0714.2004.0235.x
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发表时间：
2004-08-01
影响因子：
3.3
通讯作者：
Boecking, A
中科院分区：
文献类型：
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作者：
Maraki, D;Becker, J;Boecking, A
背景技术背景：本研究的目的是评估脱落细胞学（EC）和DNA图像细胞术应用于可疑的口腔病变的诊断准确性与同步histologic.METHODS：刷和手术刀活检98例可疑的口腔病变。在情况下，其中EC显示恶性或可疑细胞，核DNA含量进行了测量，使用电视图像分析system.RESULTS：在98个口腔病变的细胞学和组织学诊断显示75没有恶性或发育不良的迹象。在23例病例中，细胞学检查结果为肿瘤细胞阳性（15例）、可疑（4例）或可疑（4例）。其中19例DNA细胞计数显示为非整倍体。结论：细胞学结合DNA细胞学诊断口腔上皮性瘤变的敏感性高，特异性强，无创性，患者依从性好。
BACKGROUND: The aim of this study was to evaluate the diagnostic accuracy of exfoliative cytology (EC) and DNA-image cytometry applied to suspicious oral lesions compared with synchronous histology.METHODS: Brush- and scalpel biopsies were obtained from 98 patients with suspicious oral lesions. In cases, in which EC revealed malignant or suspicious cells, nuclear DNA-contents were measured using a TV image analysis system.RESULTS: Among 98 oral lesions both cytological and histological diagnosis showed no sign of malignancy or dysplasia in 75. In 23 cases cytology yielded tumor cell-positive (15), suspicious (four) or doubtful (four) results. DNA-cytometry showed aneuploidy in 19 of these. The comparison between cytological diagnosis combined with DNA-cytometry and biopsy-histology resulted in a sensitivity of 100% and a specificity of 97.4%.CONCLUSION: In conclusion, cytology with DNA-cytometry is a highly sensitive, specific and non-invasive method for the early diagnosis of oral epithelial neoplasia, showing excellent compliance among patients.