Visible-Light-Triggered Uncaging of Carbonyl Sulfide for Hydrogen Sulfide (H2S) Release
Visible-Light-Triggered Uncaging of Carbonyl Sulfide for Hydrogen Sulfide (H2S) Release
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DOI：
10.1021/acs.orglett.7b02259
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发表时间：
2017-09-15
期刊：
影响因子：
5.2
通讯作者：
Chakrapani, Harinath
中科院分区：
文献类型：
--
作者：
Sharma, Ajay Kumar;Nair, Mrutyunjay;Chakrapani, Harinath
硫化氢（H2S）的生成具有挑战性，很少有方法能够局部输送这种气体。本文报道了一种硼基二吡啶氨基甲酸酯（BDP-H2S），在470 nm可见光下释放生成羰基硫化物（COS）， COS在碳酸酐酶（一种普遍存在的酶）的存在下迅速水解为H2S。
Generation of hydrogen sulfide (H2S) is challenging and few methods are capable of localized delivery of this gas. Here, a boron dipyrromethene-based carbamothioate (BDP-H2S) that is uncaged by visible light of 470 nm to generate carbonyl sulfide (COS), which is rapidly hydrolyzed to H2S in the presence of carbonic anhydrase, a widely prevalent enzyme, is reported.