Polygenic Risk and the Course of Attention-Deficit/Hyperactivity Disorder From Childhood to Young Adulthood: Findings From a Nationally Representative Cohort.
Polygenic Risk and the Course of Attention-Deficit/Hyperactivity Disorder From Childhood to Young Adulthood: Findings From a Nationally Representative Cohort.
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DOI：
10.1016/j.jaac.2020.12.033
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发表时间：
2021-09
影响因子：
13.3
通讯作者：
Arseneault L
中科院分区：
文献类型：
--
作者：
Agnew-Blais JC;Belsky DW;Caspi A;Danese A;Moffitt TE;Polanczyk GV;Sugden K;Wertz J;Williams BS;Lewis CM;Arseneault L
了解注意力缺陷/多动障碍（ADHD）的遗传风险是否与儿童期和青年期的疾病过程相关。参与者来自环境风险（E-Risk）纵向双胞胎研究，这是一项基于人口的2，232对双胞胎的出生队列。ADHD在5岁、7岁、10岁和12岁时通过母亲和老师的报告进行评估，在18岁时通过自我报告进行评估。使用ADHD病例状态的全基因组关联研究创建多基因风险评分（PRS）。在儿童期的多个时间点和从儿童早期到青春期的纵向时间点检查与PRS的关联。我们调查了ADHD PRS和病程到青年期，如ADHD缓解，持续和迟发所反映的。ADHD PRS较高的参与者符合ADHD诊断标准的风险增加（比值比范围从10岁的1.17到12岁的1.54），并且在5岁，7岁，10岁和12岁时症状升高。从5岁到12岁，较高的PRS与更多的多动/冲动（发生率比= 1.18）和注意力不集中（发生率比= 1.14）纵向相关。在年轻的成年期，持续性ADHD的参与者表现出最高的PRS（平均PRS = 0.37），其次是缓解的参与者（平均PRS = 0.21）;两组的PRS都高于对照组（平均PRS =-0.03），但彼此之间没有显著差异。晚发性ADHD的参与者没有表现出ADHD，抑郁症，酒精依赖或大麻使用障碍的PRS升高。来自病例对照全基因组关联研究的遗传风险评分可能不仅与精神健康障碍的发病率相关，而且与理解精神健康障碍的纵向病程相关。
To understand whether genetic risk for attention-deficit/hyperactivity disorder (ADHD) is associated with the course of the disorder across childhood and into young adulthood. Participants were from the Environmental Risk (E-Risk) Longitudinal Twin Study, a population-based birth cohort of 2,232 twins. ADHD was assessed at ages 5, 7, 10, and 12 with mother- and teacher-reports and at age 18 with self-report. Polygenic risk scores (PRSs) were created using a genome-wide association study of ADHD case status. Associations with PRS were examined at multiple points in childhood and longitudinally from early childhood to adolescence. We investigated ADHD PRS and course to young adulthood, as reflected by ADHD remission, persistence, and late onset. Participants with higher ADHD PRSs had increased risk for meeting ADHD diagnostic criteria (odds ratios ranging from 1.17 at age 10 to 1.54 at age 12) and for elevated symptoms at ages 5, 7, 10, and 12. Higher PRS was longitudinally associated with more hyperactivity/impulsivity (incidence rate ratio = 1.18) and inattention (incidence rate ratio = 1.14) from age 5 to age 12. In young adulthood, participants with persistent ADHD exhibited the highest PRS (mean PRS = 0.37), followed by participants with remission (mean PRS = 0.21); both groups had higher PRS than controls (mean PRS = −0.03), but did not significantly differ from one another. Participants with late-onset ADHD did not show elevated PRS for ADHD, depression, alcohol dependence, or marijuana use disorder. Genetic risk scores derived from case-control genome-wide association studies may have relevance not only for incidence of mental health disorders, but also for understanding the longitudinal course of mental health disorders.
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DOI：
10.1093/bioinformatics/btu848
发表时间：
2015-05-01
期刊：
Bioinformatics (Oxford, England)
影响因子：
--
作者：
Euesden J;Lewis CM;O'Reilly PF
通讯作者：
O'Reilly PF
DOI：
10.1016/j.jaac.2010.06.008
发表时间：
2010-09
影响因子：
13.3
作者：
Neale BM;Medland SE;Ripke S;Asherson P;Franke B;Lesch KP;Faraone SV;Nguyen TT;Schäfer H;Holmans P;Daly M;Steinhausen HC;Freitag C;Reif A;Renner TJ;Romanos M;Romanos J;Walitza S;Warnke A;Meyer J;Palmason H;Buitelaar J;Vasquez AA;Lambregts-Rommelse N;Gill M;Anney RJ;Langely K;O'Donovan M;Williams N;Owen M;Thapar A;Kent L;Sergeant J;Roeyers H;Mick E;Biederman J;Doyle A;Smalley S;Loo S;Hakonarson H;Elia J;Todorov A;Miranda A;Mulas F;Ebstein RP;Rothenberger A;Banaschewski T;Oades RD;Sonuga-Barke E;McGough J;Nisenbaum L;Middleton F;Hu X;Nelson S;Psychiatric GWAS Consortium: ADHD Subgroup
通讯作者：
Psychiatric GWAS Consortium: ADHD Subgroup
影响因子：
25.8
作者：
Pingault JB;Viding E;Galéra C;Greven CU;Zheng Y;Plomin R;Rijsdijk F
通讯作者：
Rijsdijk F
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
影响因子：
7.6
作者：
Moffitt, TE
通讯作者：
Moffitt, TE