ACQUIRED DYSFUNCTION DUE TO THE CIRCULATION OF EXHAUSTED PLATELETS
ACQUIRED DYSFUNCTION DUE TO THE CIRCULATION OF EXHAUSTED PLATELETS
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DOI：
10.1016/0002-9343(80)90383-6
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发表时间：
1980-01-01
影响因子：
5.9
通讯作者：
MANNUCCI, PM
中科院分区：
文献类型：
--
作者：
PARETI, FI;CAPITANIO, A;MANNUCCI, PM
获得性血小板功能缺陷8例，表现为各种临床症状，3例肾移植排斥反应，3例溶血性尿毒症综合征或血栓性血小板减少性紫癜，1例急性消耗性凝血病由于不相容的输血和1例系统性红斑狼疮。他们表现出血小板聚集缺陷，腺嘌呤核苷酸和血清素水平降低，胺的摄取和储存异常。出血时间比血小板计数预测的时间更长。这些异常与先天性储存池缺陷患者发生的异常惊人相似。获得性缺陷被认为与血小板在体内暴露于释放反应的诱导剂（如受损的内皮、凝血酶和免疫复合物）后循环中存在耗尽的血小板有关。血小板功能受损可加重基础疾病的出血倾向。
An acquired platelet functional defect was present in 8 patients who presented with various clinical conditions, 3 with renal allograft rejection, 3 with the hemolytic uremic syndrome or thrombotic thrombocytopenic purpura, 1 with acute consumption coagulopathy due to an incompatible transfusion and 1 with systemic lupus erythematosus. They showed defective platelet aggregation and reduced levels of adenine nucleotides and serotonin with abnormal uptake and storage of the amine. The bleeding time was more prolonged than predicted from the platelet count. These abnormalities were strikingly similar to those occurring in patients with congenital storage pool deficiency. The acquired defect is thought to be related to the presence in the circulation of exhausted platelets following their in vivo exposure to inducers of the release reaction such as damaged endothelium, thrombin and immune complexes. The bleeding tendency of the underlying diseases might be aggravated by the impairment of platelet function.