Inflammatory response in cervical intraepithelial neoplasia and squamous cell carcinoma of the uterine cervix
Inflammatory response in cervical intraepithelial neoplasia and squamous cell carcinoma of the uterine cervix
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DOI：
10.1016/s0344-0338(97)80102-1
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发表时间：
1997-01-01
影响因子：
2.8
通讯作者：
Kopolovic, J
中科院分区：
文献类型：
--
作者：
Davidson, B;Goldberg, I;Kopolovic, J
白细胞浸润是大多数实体瘤的形态学特征，包括宫颈上皮内瘤变（GIN）和浸润性癌。我们研究了50例CIN I， CIN II, CIN III，浸润性癌和正常对照，以评估炎症反应。两种标志物——CD68（巨噬细胞特异性标志物）和ICAM-1（存在于白细胞、血管和上皮细胞上）被采用。结果显示，两种标志物在正常、CIN II和CIN III病变中的炎症细胞计数相似，而CIN i的计数较低。浸润性癌中CD68和ICAM-1的浸润密度均有统计学意义的增加（p < 0.002）。两种标记的巨噬细胞密度与人乳头瘤病毒（HPV）的存在、特定类型或合并感染几种类型的证据无关。我们的结论是，宫颈上皮内瘤变的炎症反应是不充分的。浸润性癌细胞计数升高可能反映了对侵袭的反应，而不是肿瘤特异性免疫反应。CIN病变炎症的抑制可能与这些病变中活跃的病毒复制有关。
Leukocytic infiltrates are a morphologic feature of most solid tumors, including uterine cervical intraepithelial neoplasia (GIN) and invasive carcinoma. We have studied 50 cases of CIN I, CIN II, CIN III, invasive carcinoma and normal controls in order to evaluate the inflammatory response. Two markers - CD68, a macrophage-specific marker, and ICAM-1, present on leukocytes, blood vessels and epithelial cells - were employed. Results have demonstrated similar inflammatory cell counts in normal, CIN II and CIN III lesions by both markers, and lower counts for CIN I. Invasive carcinomas demonstrated a statistically significant increase in infiltrate density by both CD68 (p < 0.002) and ICAM-1 (p < 0.05). Macrophage density by either marker did not correlate with Human Papillomavirus (HPV) presence, specific type, or evidence of co-infection with several types. We conclude that the inflammatory response to cervical intraepithelial neoplasia is inadequate. The elevated cell counts in invasive carcinomas may reflect a reaction towards invasion rather than tumor-specific immune response. Depression of inflammation in CIN I lesions may be associated with active viral replication in these lesions.