Polycomb group proteins: Novel molecules associated with ultraviolet A-induced photoaging of human skin.
Polycomb group proteins: Novel molecules associated with ultraviolet A-induced photoaging of human skin.
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多梳族蛋白：与紫外线 A 诱导的人类皮肤光老化相关的新型分子
DOI：
10.3892/etm.2017.4807
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发表时间：
2017-09
影响因子：
2.7
通讯作者：
Zhang L
中科院分区：
文献类型：
--
作者：
Wu Z;Zhang L
表观遗传抑制因子聚合组(PcG)蛋白被认为在许多细胞过程中发挥作用，包括癌症发生、衰老、细胞凋亡和DNA修复。本研究利用长波紫外线A(UVA)照射人皮肤成纤维细胞(HSFs)和胚胎皮肤成纤维细胞(ESFS)，以模拟皮肤的光老化。细胞增殖、细胞凋亡、透明质酸(HA)含量及逆转录定量聚合酶链式反应检测结果显示，PcG关键蛋白基因(Bmi-1和EZH2)的表达水平发生改变。此外，这些基因的表达水平与调节HA合成的酶的表达有关。此外，PcG蛋白在HSFs和ESFS中的表达水平不同，这表明PcG蛋白在UVA诱导的成纤维细胞老化过程中发挥了改变HA合成的作用。这一信号通路可能代表了一种新的调节皮肤光老化的分子机制。本研究的发现为人类皮肤光老化的潜在机制提供了重要的见解。需要进一步的研究来阐明皮肤老化的分子机制，并确定光老化的临床治疗靶点。
Epigenetic repressor polycomb group (PcG) proteins are thought to serve a role in a number of cellular processes, including carcinogenesis, senescence, apoptosis and DNA repair. In the present study, long-wave ultraviolet A (UVA) was used to irradiate human skin fibroblasts (HSFs) and embryonic skin fibroblasts (ESFs) in order to simulate photoaging of the skin. The results of cell proliferation, apoptosis, hyaluronic acid (HA) content and reverse transcription-quantitative polymerase chain reaction assays revealed that the expression levels of genes encoding key PcG proteins (BMI-1 and EZH2) were altered. In addition, the expression levels of these genes were associated with the expression of enzymes that regulate HA synthesis. Furthermore, the expression levels of PcG proteins differed between HSFs and ESFs, suggesting that PcG proteins serve a role in altering HA synthesis during the UVA-induced fibroblast aging process. This signaling pathway may represent a novel molecular mechanism regulating the photoaging of the skin. The findings of the present study provide important insights into the underlying mechanisms of photoaging of the human skin. Further studies are required to clarify the molecular mechanisms underling skin aging and to identify targets for the clinical treatment of photoaging.
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影响因子：
7.8
作者：
Midgley AC;Bowen T;Phillips AO;Steadman R
通讯作者：
Steadman R
DOI：
10.1042/bss0670151
发表时间：
2001-01-01
期刊：
NEURONAL SIGNAL TRANSDUCTION AND ALZHEIMER'S DISEASE
影响因子：
--
作者：
Mattson, MP;Gary, DS;Duan, WZ
通讯作者：
Duan, WZ
影响因子：
7.2
作者：
Merini, Wiam;Calonje, Myriam
通讯作者：
Calonje, Myriam
影响因子：
4.8
作者：
Midgley, Adam C.;Rogers, Mathew;Steadman, Robert
通讯作者：
Steadman, Robert
DOI：
10.1083/jcb.201504035
发表时间：
2015-11-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Cesarini E;Mozzetta C;Marullo F;Gregoretti F;Gargiulo A;Columbaro M;Cortesi A;Antonelli L;Di Pelino S;Squarzoni S;Palacios D;Zippo A;Bodega B;Oliva G;Lanzuolo C
通讯作者：
Lanzuolo C