FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients
FMRI connectivity analysis of acupuncture effects on the whole brain network in mild cognitive impairment patients
复制标题
针刺对轻度认知障碍患者全脑网络影响的 FMRI 连接分析
DOI：
10.1016/j.mri.2012.01.003
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发表时间：
2012-06-01
影响因子：
2.5
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Feng, Yuanyuan;Bai, Lijun;Tian, Jie
患有轻度认知障碍(MCI)的老年人进展为阿尔茨海默病的风险增加，使其成为适合研究的条件。虽然使用针灸作为治疗MCI的补充治疗方法在世界某些地区很受欢迎，但其潜在的机制仍不清楚。我们试图与健康对照组(HC)比较，研究针刺对MCI患者全脑功能连接的影响。功能磁共振成像实验采用两种不同的模式，即深针(DA)和浅针(SA)，穴位为KI3。我们首先确定了在静息状态下，与HC相比，MCI组显示出功能连接异常的区域，随后测试了这些区域是否可以被针灸调制。然后，我们进行MCI和HC的比较，以检验两组在刺激后静息脑中是否存在特定的调制模式。最后，将各组的DA与SA进行比较，以检验不同针刺深度的针刺效果。我们发现，在静息状态下，颞叶区域(海马体、丘脑、梭形回)表现出异常的功能连接。这些区域与记忆编码和提取有关。此外，我们还发现，针刺后MCI患者与异常区域相关的功能连通性发生了显著变化。与MC相比，MCI患者刺激后静息脑区与颞区的相关性增强。与SA相比，DA条件下与颞区相关的相关性显著增加。针刺后记忆相关脑区的相关性增强可能与针刺治疗MCI的疗效有关。DA和SA之间的不同调节模式可能表明，针刺深部肌肉插入是取得显著临床效果的必要手段。(C)2012 Elsevier Inc.保留所有权利。
The increased risk for the elderly with mild cognitive impairment (MCI) to progress to Alzheimer's disease makes it an appropriate condition for investigation. While the use of acupuncture as a complementary therapeutic method for treating MCI is popular in certain parts of the world, the underlying mechanism is still elusive. We sought to investigate the acupuncture effects on the functional connectivity throughout the entire brain in MCI patients compared to healthy controls (HC). The functional magnetic resonance imaging experiment was performed with two different paradigms, namely, deep acupuncture (DA) and superficial acupuncture (SA), at acupoint KI3. We first identified regions showing abnormal functional connectivity in the MCI group compared to HC during the resting state and subsequently tested whether these regions could be modulated by acupuncture. Then, we made the comparison of MCI vs. HC to test whether there were any specific modulatory patterns in the poststimulus resting brain between the two groups. Finally, we made the comparisons of DA vs. SA in each group to test the effect of acupuncture with different needling depths. We found the temporal regions (hippocampus, thalamus, fusiform gyms) showing abnormal functional connectivity during the resting state. These regions are implicated in memory encoding and retrieving. Furthermore, we found significant changes in functional connectivity related with the abnormal regions in MCI patients following acupuncture. Compared to MC, the correlations related with the temporal regions were enhanced in the poststimulus resting brain in MCI patients. Compared to SA, significantly increased correlations related with the temporal regions were found for the DA condition. The enhanced correlations in the memory-related brain regions following acupuncture may be related to the purported therapeutically beneficial effects of acupuncture for the treatment of MCI. The heterogeneous modulatory patterns between DA and SA may suggest that deep muscle insertion of acupuncture is necessary to achieve the appreciable clinical effect. (C) 2012 Elsevier Inc. All rights reserved.