FORMALDEHYDE AND CANCER MORBIDITY AMONG MALE EMPLOYEES IN DENMARK
FORMALDEHYDE AND CANCER MORBIDITY AMONG MALE EMPLOYEES IN DENMARK
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DOI：
10.1007/bf00051411
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发表时间：
1995-07-01
影响因子：
2.3
通讯作者：
OLSEN, JH
中科院分区：
文献类型：
--
作者：
HANSEN, J;OLSEN, JH
甲醛是一种具有遗传毒性和强效动物致癌物，广泛存在于工作环境和私人住宅中。在丹麦的癌症发病率的风险在1970年至1984年期间估计标准化比例发病率（SPIR）的男子，最长的就业已举行自1964年以来，至少10年前诊断，在265家公司，其中暴露于甲醛被确定。结果不支持甲醛与肺癌相关的假设（SPIR = 1.0，410例）。结肠癌（SPIR = 1.2，166例）、肾癌（SPIR = 1.3，60例）和鼻窦癌（SPIR = 2.3，13例）的风险显著升高。对于鼻窦癌，在可能没有接触木尘（主要混杂因素）的蓝领工人中发现的相对风险为3.0（95%置信区间= 1.4-5.7）。这项研究提供了进一步的证据，表明职业暴露于甲醛会增加患鼻窦癌的风险。
Formaldehyde, a genotoxic and potent animal carcinogen, is widespread in the working environment as well as in private homes. The risk for cancer morbidity in Denmark during 1970-84 was estimated from standardized proportionate incidence ratios (SPIR) among men whose longest employment had been held since 1964, at least 10 years before diagnosis, in 265 companies in which exposure to formaldehyde was identified. The results do not support the hypothesis that formaldehyde is associated with lung cancer (SPIR = 1.0, 410 cases). Significantly elevated risks were found for cancers of the colon (SPIR = 1.2, 166 cases), kidney (SPIR = 1.3, 60 cases), and sine-nasal cavities (SPIR = 2.3, 13 cases). For sine-nasal cancer, a relative risk of 3.0 (95 percent confidence interval = 1.4-5.7) was found among blue-collar workers with no probable exposure to wood dust, the major confounder. This study provides further evidence that occupational exposure to formaldehyde increases the risk for sine-nasal cancer.