Synthesis of γ‐amino[4‐11C]butyric acid (GABA)
Synthesis of γ‐amino[4‐11C]butyric acid (GABA)
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γ-氨基[4-11C]丁酸（GABA）的合成
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
B. Långström
中科院分区：
文献类型：
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作者：
G. Antoni;B. Långström
A one-pot synthesis of no-carrier added γ-amino[4-11C]butyric acid (GABA) starting with hydrogen [11C]cyanide prepared from [11C]carbon dioxide, is presented. Hydrogen [11C]cyanide was trapped in tetrahydrofuran/potassium hydroxide in the presence of the amino polyether Kryptofix 2.2.2. A Michael addition with ethyl acrylate followed by a selective reduction and hydrolysis of the resulting amino ester gave [4-11C]GABA. The radiochemical purity of GABA was higher than 99% and the decay corrected radiochemical yield was 60–65% based on the amount of H[11C]CN used. The total synthesis time including purification was around 40 min, counted from the start of the Michael addition reaction.
无载体添加的[1-11C]腐胺的合成和生物分布。
DOI：
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发表时间：
1985
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
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作者：
McPherson,DW;Fowler,JS;Wolf,AP;Arnett,CD;Brodie,JD;Volkow,N
通讯作者：
Volkow,N