Associations of resistin with inflammation and insulin resistance in patients with type 2 diabetes mellitus
Associations of resistin with inflammation and insulin resistance in patients with type 2 diabetes mellitus
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DOI：
10.1080/00365510601032532
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发表时间：
2007-01-01
影响因子：
2.1
通讯作者：
Abdella, N. A.
中科院分区：
文献类型：
--
作者：
Mojiminiyi, O. A.;Abdella, N. A.
Objective.抵抗素与肥胖，2型糖尿病，炎症和动脉粥样硬化有关，但动物和人类研究的结果一直存在差异。本研究的目的是探讨2型糖尿病患者中的潜在作用，并评估2型糖尿病患者中的肥胖，炎症，胰岛素抵抗，代谢参数，糖尿病控制和并发症之间的相关性。材料和方法。对135例2型糖尿病患者进行空腹血糖、瘦素、胰岛素、糖化血红蛋白（HbA1c）、血脂、C反应蛋白（CRP）及全血细胞计数检测。采用单因素和多因素Logistic回归分析方法，分析肥胖、炎症、胰岛素抵抗（HOMA）、胰岛素敏感性、糖尿病控制、冠心病（CHD）和微量白蛋白尿程度等指标与EARN的关系。结果抵抗素表达有显著性差异（p
Objective. Resistin has been linked to obesity, type 2 diabetes, inflammation and atherosclerosis but the results of animal and human studies have been at variance. The purpose of this study was to investigate the potential roles of resistin in patients with type 2 diabetes and to evaluate the correlation between resistin and markers of obesity, inflammation, insulin resistance, metabolic parameters, diabetes control and complications. Material and methods. Fasting resistin, leptin, insulin, glucose, HbA1c, full lipid profile, C-reactive protein (CRP) (high sensitivity assay) and complete blood count were determined in 135 patients with type 2 diabetes. Univariate regression and multivariate logistic regression analyses were used to relate resistin with indices of obesity, inflammation, insulin resistance (homeostasis model, HOMA), insulin sensitivity, diabetic control, coronary heart disease (CHD) and degree of microalbuminuria. Results. Resistin showed significant (p