Preventive effect of human papillomavirus vaccination on the development of uterine cervical lesions in young Japanese women
Preventive effect of human papillomavirus vaccination on the development of uterine cervical lesions in young Japanese women
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DOI：
10.1111/jog.13419
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发表时间：
2017-10-01
影响因子：
1.6
通讯作者：
Terada, Yukihiro
中科院分区：
文献类型：
--
作者：
Tanaka, Hidenori;Shirasawa, Hiromitsu;Terada, Yukihiro
目的：比较20- 24岁女性接种和未接种HPV疫苗的宫颈细胞学检查结果，探讨秋田县接种HPV疫苗的效果。方法：我们对2014年1月至2016年10月期间在秋田保健财团管辖下接受宫颈癌筛查的2425名受试者进行了宫颈细胞学检查。结果：HPV疫苗接种组和未接种组宫颈细胞学异常发生率分别为0.242%（1/413）和2.04%（41/2012）。总体而言，接受HPV疫苗接种的20- 24岁女性的异常细胞学结果的患病率显著低于未接种者（P=0.011）。结论：接种HPV疫苗后4 ~ 5年内，20- 24岁妇女宫颈细胞学异常率明显低于未接种者。
Aim: To examine the effect that human papillomavirus (HPV) vaccination has had in Akita Prefecture, by comparing cervical cytology results from women aged 20-24years with or without HPV vaccination.Methods: We examined cervical cytology results from 2425 subjects who underwent cervical cancer screening under the jurisdiction of the Akita Foundation for Healthcare between January 2014 and October 2016. We compared the prevalence of cytologic abnormalities among women aged 20-24years with or without HPV vaccination.Results: The rate of atypical squamous cells of undetermined significance (ASC-US) or worse was 0.242% (1/413) with HPV vaccination, and 2.04% (41/2012) without HPV vaccination. Overall, the prevalence of abnormal cytology results was significantly lower in women aged 20-24years who had received an HPV vaccination than in those who had not (P=0.011). The reduction in the rate of abnormal cervical cytology results by HPV vaccination was 88.1%.Conclusion: Within a 4-year-5-year period following vaccination, women aged 20-24years who received an HPV vaccination had significantly lower rates of abnormal cervical cytology results than those who did not receive the vaccine.