Interleukin-15: a muscle-derived cytokine regulating fat-to-lean body composition.
Interleukin-15: a muscle-derived cytokine regulating fat-to-lean body composition.
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DOI：
10.2527/jas.2007-0458
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发表时间：
2008-04
影响因子：
3.3
通讯作者：
L. S. Quinn
中科院分区：
文献类型：
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作者：
L. S. Quinn
越来越多的文献将免疫和炎症因子与生长调节和脂肪控制联系起来：瘦体成分。最近在了解身体组成的控制方面取得了进展，这是通过识别脂肪组织产生的炎性细胞因子和其他影响身体组成的因子，这些因子通常直接作用于骨骼肌组织。脂肪源性因子如瘦素、肿瘤坏死因子-α、瘦素和脂联素已被证明通过直接作用影响肌肉代谢、蛋白质动力学或两者。这篇综述总结了最近的结果，支持存在一个互惠的肌肉脂肪信号通路，涉及释放的细胞因子IL-15从肌肉组织。细胞培养研究、短期体内研究和人类基因型关联研究均支持肌源性IL-15可通过肌肉-脂肪内分泌途径减少脂肪沉积和脂肪细胞代谢的模型。脂肪：瘦肉体成分是决定肉类生产效率的重要因素，也是肉制品的脂肪含量。IL-15信号轴的调节可能是影响肉畜生产中身体组成的一种新机制。
An increasing body of literature links immune and inflammatory factors to modulation of growth and control of fat:lean body composition. Recent progress in understanding the control of body composition has been made through identification of inflammatory cytokines and other factors produced by adipose tissue that affect body composition, often by direct effects on skeletal muscle tissue. Adipose-derived factors such as leptin, tumor necrosis factor-alpha, resistin, and adiponectin have been shown to affect muscle metabolism, protein dynamics, or both, by direct actions. This review summarizes recent results that support the existence of a reciprocal muscle-to-fat signaling pathway involving release of the cytokine IL-15 from muscle tissue. Cell culture studies, short-term in vivo studies, and human genotype association studies all support the model that muscle-derived IL-15 can decrease fat deposition and adipocyte metabolism via a muscle-to-fat endocrine pathway. Fat:lean body composition is an important factor determining the efficiency of meat production, as well as the fat content of meat products. Modulation of the IL-15 signaling axis may be a novel mechanism to affect body composition in meat animal production.