Genipin cross-linked carbon dots for antimicrobial, bioimaging and bacterial discrimination
Genipin cross-linked carbon dots for antimicrobial, bioimaging and bacterial discrimination
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DOI：
10.1016/j.colsurfb.2020.110930
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发表时间：
2020-06-01
影响因子：
5.8
通讯作者：
Shen, Jian
中科院分区：
文献类型：
--
作者：
Chu, Xiaohong;Wu, Fan;Shen, Jian
多功能碳点具有广阔的应用前景，在生物医学领域的各种应用受到了广泛的关注。细菌感染是一个常见的健康问题；开发低毒、生物相容性好的抗菌材料变得越来越重要。本文采用水热法合成了一种新型氮共掺杂碳点-genipin共价共轭物（N-CDs-GP）。对N-CDs-GP的微观结构和化学成分进行了表征。对N-CDsGP的生物相容性、稳定性、抗菌活性和荧光性能进行了评价。结果表明，N-CDs-GP具有良好的生物相容性、光稳定性和广泛的抗菌活性。此外，N-CDs-GP选择性革兰氏阳性细菌成像提供了一种更快速的细菌检测方法。N-CDs-GP具有应用于生物成像、抗菌和细菌鉴别的潜力。
Multifunctional carbon dots (CDs) present enormous potential in numerous applications and have attracted widespread attention for various applications in the biomedical field. Bacterial infection is a common health issue; the development of antibacterial materials with low toxicity and good biocompatibility is becoming more important. In this work, we synthesized a new type of nitrogen co-doped carbon dots-genipin covalent conjugate (N-CDs-GP) via hydrothermal methods. The microstructure and chemical composition of the N-CDs-GP were characterized. The biocompatibility, stability, antibacterial activity, and fluorescence performance of the N-CDsGP were assessed. The results revealed that N-CDs-GP possessed high biocompatibility, high light stability, and broad antibacterial activity. Additionally, selective Gram-positive bacterial imaging by N-CDs-GP provided a more rapid method of bacterial detection. The N-CDs-GP have the potential to be applied as bioimaging and antibacterial agents and for bacterial discrimination.