Cancer chemoprevention through the induction of apoptosis by natural compounds.
Cancer chemoprevention through the induction of apoptosis by natural compounds.
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DOI：
10.4236/jbpc.2012.32018
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发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Tanaka, T.
中科院分区：
文献类型：
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作者：
Kuno, T.;Tsukamoto, T.;Tanaka, T.
由于细胞和组织稳态是由增殖和凋亡之间的平衡介导的，因此控制这种平衡对于癌症化学预防非常重要。癌症化学预防可以通过使用逆转、抑制或预防上皮恶性肿瘤发展的天然、合成或生物化合物来实现。包括黄酮类化合物在内的天然化合物能够减少氧化应激，这是介导癌症发展的保护作用的最可能的机制。此外，体外和体内研究表明，黄酮类化合物，如 (-)-表没食子儿茶素-3-没食子酸酯 (EGCG)、槲皮素和姜黄素，可通过诱导细胞凋亡发挥作用。几种天然化合物抑制细胞增殖和血管生成。某些天然产物已被证明可以抑制核因子 kappa B (NF-kappaB) 和 Akt 信号通路的激活，这两种信号通路均能维持细胞存活和凋亡之间的稳态平衡。了解这些天然产物的机制将有助于制定更具体的预防癌症发展的策略。在这里，我们重点关注天然癌症化学预防剂诱导细胞凋亡的能力，并试图以简洁的方式强调体内 kappa 和 Akt 信号通路，为天然化合物 EGCG、槲皮素和姜黄素的预防和治疗作用提供证据。
As cell and tissue homeostasis are mediated by the balance between proliferation and apoptosis, controlling this balance is important for cancer chemoprevention. Cancer chemoprevention can be achieved by the use of natural, synthetic or biologic compounds that reverse, suppress or prevent the development of epithelial malignancies. Natural compounds including flavonoids are able to reduce oxidative stress, which is the most likely mechanism mediating the protective effects against cancer development. In addition, in vitro and in vivo studies have suggested that flavonoids, such as (-)-epigallocatechin-3-gallete (EGCG), quercetin, and curcumin, act by induction of apoptosis. Several natural compounds inhibit cell proliferation and angiogenesis. Certain natural products have been shown to inhibit the activation of nuclear factor kappa B (NF-kappaB) and Akt signaling pathways, both of which are known to maintain a homeostatic balance between cell survival and apoptosis. Understanding the mechanism of these natural products will contribute to the development of more specific preventive strategies against cancer development. Here we focus on the ability of natural cancer chemopreventive agents to induce apoptosis, and attempt to provide evidence for the preventive and therapeutic effects of natural compounds, EGCG, quercetin, and curcumin, in a succinct manner highlighting kappa and Akt signaling pathways in vivo.