DNA-BINDING COMPOUNDS .5. SYNTHESIS AND CHARACTERIZATION OF BORON-CONTAINING BIBENZIMIDAZOLES RELATED TO THE DNA MINOR-GROOVE BINDER, HOECHST-33258
DNA-BINDING COMPOUNDS .5. SYNTHESIS AND CHARACTERIZATION OF BORON-CONTAINING BIBENZIMIDAZOLES RELATED TO THE DNA MINOR-GROOVE BINDER, HOECHST-33258
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DOI：
10.1071/ch9940247
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发表时间：
1994-01-01
影响因子：
1.1
通讯作者：
WHITTAKER, ARD
中科院分区：
文献类型：
--
作者：
KELLY, DP;BATEMAN, SA;WHITTAKER, ARD
报道了四种与DNA小沟结合剂Hoechst 33258有关的新型含硼联苯并咪唑的合成与表征。此类化合物，特别是其富含B-10的形式，具有作为用于治疗癌症的硼中子捕获疗法的药剂的潜力。
The synthesis and characterization of four novel boron-containing bibenzimidazoles related to the DNA minor groove binder Hoechst 33258 are reported. Such compounds, particularly their B-10-enriched forms, have potential as agents for boron neutron capture therapy which is used in the treatment of cancers.