Paired transcranial magnetic stimulation protocols reveal a pattern of inhibition and facilitation in the human parietal cortex
Paired transcranial magnetic stimulation protocols reveal a pattern of inhibition and facilitation in the human parietal cortex
复制标题
DOI：
10.1111/j.1469-7793.2000.00461.x
复制
发表时间：
2000-12-01
影响因子：
5.5
通讯作者：
Rossini, PM
中科院分区：
文献类型：
--
作者：
Oliveri, M;Caltagirone, C;Rossini, PM
1.成对经颅磁刺激（TMS）可以诱导运动皮层的皮层内抑制（ICI）和易化（ICF）。虽然在实验动物中得到证实，但在人类顶叶感觉皮质中存在皮质内抑制和兴奋回路尚未被记录。本研究旨在探讨顶叶皮层成对经颅磁刺激对对侧触觉感知的影响. 15名健康受试者参与了一项任务的歧视的电刺激在近阈值强度的感官知觉超过左手拇指。在手指刺激呈现的各种延迟后，在右后顶叶上用焦点线圈提供成对的TMS。研究了条件刺激和测试刺激之间不同刺激间隔（ISI：1，3，5，7，10和15 ms）对触觉感知的影响。条件刺激强度设为运动阈的70%，测试TMS强度设为运动阈的130%.单脉冲阈上TMS干扰手指刺激的感知，而阈下刺激，如“条件反射”刺激对感觉知觉没有影响。配对TMS差异影响的性能取决于ISI。在ISI为1 ms时，与单脉冲TMS相比，成对TMS刺激导致了操作的显著恶化;在ISI为5 ms时，与单脉冲TMS相比，成对TMS刺激导致了操作的显著易化，恢复了基线操作水平.这些结果表明，成对的TMS可以揭示人类皮质中ICI和ICF的选择性模式。
1. Intracortical inhibition (ICI) and facilitation (ICF) of the human motor cortex can be induced by paired transcranial magnetic stimulation (TMS). Although demonstrated in experimental animals, the existence of intracortical inhibitory and excitatory circuits in parietal sensory cortex has not been documented in humans. The aim of this study was to investigate the effects of paired TMS of the parietal cortex on contralateral tactile perception.2. Fifteen healthy subjects were involved in a task of discrimination of electrical stimuli delivered at near-threshold intensity of sensory perception over the left thumb. Paired TMS was delivered with a focal coil on the right posterior parietal lobe after various delays from the presentation of finger stimuli. The effects of different interstimulus intervals (ISI: 1, 3, 5, 7, 10 and 15 ms) between the conditioning and the test TMS stimulus on tactile perception were studied. The conditioning stimulus intensity was set at 70% of motor threshold, while test TMS intensity was 130% of motor threshold.3. Single pulse suprathreshold TMS interfered with the perception of finger stimuli, while subthreshold stimuli such as the 'conditioning' stimuli had no effect on sensory perception. Paired TMS differentially influenced the performance depending on the ISI. At an ISI of 1 ms, paired TMS stimuli induced a significant worsening of the performance compared with single plulse TMS; at an ISI of 5 ms, paired TMS stimuli induced a significant facilitation of the performance compared with single pulse TMS, restoring baseline performance levels.4. These results suggest that paired TMS can reveal a selectgive pattern of ICI and ICF in the human cortex.