Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: Association between striatal dopamine markers and motor hyperactivity
Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/hyperactivity disorder: Association between striatal dopamine markers and motor hyperactivity
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DOI：
10.1016/j.biopsych.2004.11.009
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发表时间：
2005-02-01
影响因子：
10.6
通讯作者：
Farde, L
中科院分区：
文献类型：
--
作者：
Jucaite, A;Fernell, E;Farde, L
背景资料：注意力缺陷多动障碍（ADHD）儿童的多动-注意力不集中行为是由多巴胺传递改变引起的，这一假说是基于遗传研究和精神兴奋剂的疗效。大多数以前的正电子发射断层扫描（PET）和单光子发射断层扫描（SPET）的研究表明，基底神经节中的多巴胺标记物的结合改变。然而，神经化学紊乱的功能作用知之甚少。本研究的目的是研究多巴胺转运蛋白（DAT）和多巴胺D2受体（D2 R）结合在青少年ADHD和搜索其与认知功能的关系，以及运动hyperactivity.Methods：12例ADHD青少年和10名年轻人进行了PET检查使用选择性放射性配体[（11）] PE 2 I和[C-11]雷氯必利，指数DAT和D2 R密度。使用简化的参考组织模型计算结合电位（BP）值。注意力和运动行为进行了调查与连续性能任务（CPT）和运动measurements.Results：[C-11] PE 2 I和[C-11]雷氯必利在ADHD儿童的纹状体的BP值没有显着差异，从年轻的成年对照组。然而，在中脑，患有ADHD的儿童的DAT的BP值显著较低（16%; p = 0.03）。右侧尾状核多巴胺D2受体结合与运动活动增加显著相关（r = .70，p = .01）。结论：中脑DAT的BP值较低，表明ADHD受试者的多巴胺信号传导发生了改变。多巴胺信号的改变可能与运动多动有因果关系，可能被认为是ADHD的潜在内在表型。
Background: The hypothesis that altered dopamine transmission underlies hyperactive-inattentive behavior in children with attention-deficit/hyperactivity disorder (ADHD) is based on genetic studies and the efficacy of psychostimulants. Most of previous positron emission tomography (PET) and single photon emission tomography (SPET) studies have shown altered binding of dopamine markers in the basal ganglia. Yet, the functional role of the neurochemical disturbances are poorly understood. The purpose of our study was to examine dopamine transporter (DAT) and dopamine D2 receptor (D2R) binding in adolescents with ADHD and to search for its relationship with cognitive functions as well as locomotor hyperactivity.Methods: Twelve adolescents with ADHD and 10 young adults were examined with PET using the selective radioligands [(11)]PE2I and [C-11]raclopride, indexing DAT and D2R density. The simplified reference tissue model was used to calculate binding potential (BP) values. Attention and motor behavior were investigated with a continuous performance task (CPT) and motion measurements.Results: The BP value for [C-11]PE2I and [C-11]raclopride in the striatum of children with ADHD did not differ from that of the young adult control subjects. In the midbrain, however, the BP values for DAT were significantly lower (16%; p = .03) in children with ADHD. Dopamine D2 receptor binding in the right caudate nucleus correlated significantly with increased motor activity (r = .70, p = .01).Conclusions: The lower BP values for DAT in the midbrain suggest that dopamine signaling in subjects with ADHD is altered. Altered dopamine signaling might have a causal relationship to motor hyperactivity and might be considered as a potential endophenotype of ADHD.