Hypoxia related long non-coding RNAs in ischemic stroke.
Hypoxia related long non-coding RNAs in ischemic stroke.
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缺血性中风中缺氧相关的长非编码RNA
DOI：
10.1016/j.ncrna.2021.10.001
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发表时间：
2021-12
影响因子：
5
通讯作者：
Chen X
中科院分区：
文献类型：
--
作者：
Yao J;Du Y;Liu J;Gareev I;Yang G;Kang X;Wang X;Beylerli O;Chen X
脑卒中死亡率和致残率高，造成了巨大的社会负担，其中缺血性脑卒中占85%。近年来，人们逐渐发现长链非编码RNA（lncRNA）在缺血性脑卒中中发挥重要的调控作用。脑血流减少或中断引起的缺氧导致lncRNA表达的变化，进而影响疾病的进展。本文就缺血性脑卒中中缺氧相关lncRNA的表达及其相关分子机制的研究进展作一综述。考虑到缺氧诱导因子（hypoxia-inducible factor，HIF）是缺氧过程中的重要调节因子，本研究主要关注HIF相关的lncRNA，即调节HIF表达或受HIF调节的lncRNA，进一步揭示其在脑缺血缺氧后的发病机制和适应性变化，寻找有效的生物标志物和治疗靶点。
With high rates of mortality and disability, stroke has caused huge social burden, and 85% of which is ischemic stroke. In recent years, it is a progressive discovery of long non-coding RNA (lncRNA) playing an important regulatory role throughout ischemic stroke. Hypoxia, generated from reduction or interruption of cerebral blood flow, leads to changes in lncRNA expression, which then influence disease progression. Therefore, we reviewed studies on expression of hypoxia-related lncRNAs and relevant molecular mechanism in ischemic stroke. Considering that hypoxia-inducible factor (HIF) is a crucial regulator in hypoxic progress, we mainly focus on the HIF-related lncRNA which regulates the expression of HIF or is regulated by HIF, further reveal their pathogenesis and adaption after brain ischemia and hypoxia, so as to find effective biomarker and therapeutic targets.