Effects on ethanol on serum electrolytes and respiration in euthyroid and hyperthyroid rats.
Effects on ethanol on serum electrolytes and respiration in euthyroid and hyperthyroid rats.
复制标题
乙醇对甲状腺功能正常和甲状腺功能亢进大鼠血清电解质和呼吸的影响。
DOI：
10.1016/0041-008x(75)90207-0
复制
发表时间：
1975
影响因子：
3.8
通讯作者：
A. Pösö
中科院分区：
文献类型：
--
作者：
M. Hillbom;A. Pösö
单次大剂量乙醇（3 g/kg）经口给药后12小时内导致三碘甲状腺原氨酸（0.15 mg/kg/天，连续6天）预处理的大鼠死亡。与给予乙醇后3小时在甲状腺功能正常对照中观察到的轻微代谢性和呼吸性酸中毒相比，三碘甲状腺原氨酸预处理的大鼠仅出现了较轻的呼吸性酸中毒。乙醇给药后3小时，甲状腺功能亢进和甲状腺功能正常大鼠的血清Na+、Cl-、K+、Ca 2+和Mg 2+浓度以及红细胞K+含量均在正常范围内。用4-甲基吡唑或吡硫辛预处理不影响三碘甲状腺原氨酸中毒大鼠乙醇给药后的死亡率或死亡时间进程。它的结论是，由乙醇引起的呼吸抑制并没有发挥任何显着的作用，在甲状腺功能亢进状态下的乙醇的毒性增加。血糖或离子紊乱也不足以成为死亡的主要原因。结果表明，在甲状腺功能亢进状态下，中枢神经系统对高乙醇浓度本身的组织敏感性增加，但导致这种现象的实际机制仍未得到解决。
A single large peroral dose of ethanol (3 g/kg) caused death within 12 hr after administration to rats pretreated with triiodothyronine (0.15 mg/kg/day on 6 successive days). Compared with the slight combined metabolic and respiratory acidosis observed in euthyroid controls 3 hr after ethanol administration, the triiodothyronine-pretreated rats developed only a milder acidosis of respiratory origin. Concentrations of serum Na+, Cl−, K+, Ca2+, and Mg2+as well as red cell K+content were within normal limits in both hyper- and euthyroid rats 3 hr after ethanol administration. Pretreatment with 4-methylpyrazole or pyrithioxin did not affect the mortality rate or the time course of mortality after ethanol administration in the triiodothyronine-intoxicated rats. It is concluded that respiratory depression induced by ethanol does not play any significant role in the increased toxicity of ethanol in the hyperthyroid state. Nor are blood glucose or ion disturbances great enough to afford the primary cause of death. The results suggest that tissue sensitivity in the central nervous system to high ethanol concentrations per se is increased in the hyperthyroid state, but the actual mechanisms which contribute to this phenomenon are still unresolved.