The role of A20 in the pathogenesis of lymphocytic malignancy.
The role of A20 in the pathogenesis of lymphocytic malignancy.
复制标题
A20在淋巴细胞恶性肿瘤发病机制中的作用
DOI：
10.1186/1475-2867-12-44
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发表时间：
2012-11-07
影响因子：
5.8
通讯作者：
Li Y
中科院分区：
文献类型：
--
作者：
Zhang F;Yang L;Li Y
Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently, a number of studies have shown that the deletion or mutation of A20, a negative regulator of NF-κB, is frequently found in lymphomas, suggesting that it may be a linker between the altered immune response and leukemogenesis. The aim of this review is to summarize current findings of the A20 biological functions and its molecular mechanism as a tumor suppressor and immune regulator. The identification of A20 mutations and deletions in lymphocytic malignancy and the predictive significance of these aberrations are also reviewed.
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