4 NEW MYCOTOXINS OF ASPERGILLUS-CLAVATUS RELATED TO TRYPTOQUIVALINE
4 NEW MYCOTOXINS OF ASPERGILLUS-CLAVATUS RELATED TO TRYPTOQUIVALINE
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DOI：
10.1021/jo00422a015
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发表时间：
1977-01-01
影响因子：
3.6
通讯作者：
TOWNSEND, JM
中科院分区：
文献类型：
--
作者：
BUCHI, G;LUK, KC;TOWNSEND, JM
羟胺去甲色基喹禾灵（2）和3种仲胺脱氧色基喹禾灵（3）、脱氧去甲色基喹禾灵（4）和脱氧去甲色基喹禾灵酮（8）是A. clavatus。[The真菌是从一个泰国家庭发现的霉菌感染的大米中收集的几种真菌之一，该家庭的一名儿童死于不明中毒。伴随有2种先前描述的震颤产生剂色喹瓦林（1）和去甲色喹瓦龙（7）。用间氯过苯甲酸将仅有的弱碱性仲胺3、4和8氧化成相应的羟胺1、2。
The hydroxylamine nortryptoquivaline (2) and the 3 secondary amines deoxytryptoquivaline (3), deoxynortryptoquivaline (4) and deoxynortryptoquivalone (8) were found to be toxic metabolites of A. clavatus. [The fungus was one of several collected from mold-infested rice found in a Thai household where a child died of an unidentified toxicosis.] They were accompanied by the 2 previously described tremor producing agents tryptoquivaline (1) and nortryptoquivalone (7). The only weakly basic secondary amines 3, 4 and 8 were oxidized to the corresponding hydroxylamines 1, 2 with m-chlorperbenzoic acid.