Picrotoxin-sensitive receptors mediate γ-aminobutyric acid-induced modulation of synaptic plasticity in rat superior cervical ganglion
Picrotoxin-sensitive receptors mediate γ-aminobutyric acid-induced modulation of synaptic plasticity in rat superior cervical ganglion
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DOI：
10.1016/s0006-8993(97)00021-8
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发表时间：
1997-03
期刊：
影响因子：
2.9
通讯作者：
G. Burgos;F. I. Biali;D. Cardinali
中科院分区：
文献类型：
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作者：
G. Burgos;F. I. Biali;D. Cardinali
γ-氨基丁酸（GABA）可阻止上级颈神经节（SCG）突触效能的活动依赖性变化。本文研究了印防己毒素（PTX）对GABA介导的大鼠上皮层突触传递长时程增强（LTP）抑制的影响。复合动作电位记录在神经节前神经刺激后的颈内动脉节后神经的细胞外。PTX（100 μM）可拮抗外源性GABA（250 μM）对强强直刺激（20 Hz，20 s，超大刺激，用六甲双铵部分阻断传递）引起的LTP的抑制作用。此外，单独的PTX（50 μM）通过弱强直（20 Hz，5 s，次最大刺激）促进LTP的诱导。这些结果进一步支持了以前的数据表明，激活GABAA样受体可以防止在这个外周突触突触可塑性的发生。©1997 Elsevier Science B. V.保留所有权利。
Activity-dependent changes of synaptic efficacy in the superior cervical ganglion (SCG) can be prevented by γ-aminobutyric acid (GABA). We have studied the effects of picrotoxin (PTX) on GABA-mediated inhibition of long-term potentiation (LTP) of synaptic transmission in the rat SCG. Compound action potentials were recorded extracellularly in the postganglionic internal carotid nerve in response to preganglionic nerve stimulation. PTX (100 μM) antagonized the inhibition by exogenous GABA (250 μM) of LTP induced by strong tetanic stimulation (20 Hz, 20 s, supramaximal stimulation, partial blockade of transmission by hexamethonium). Additionally, PTX alone (50 μM) facilitated the induction of LTP by a weak tetanus (20 Hz, 5 s, submaximal stimulation). These results further support previous data indicating that activation of GABAA-like receptors can prevent the occurrence of synaptic plasticity at this peripheral synapse. ©1997 Elsevier Science B.V. All rights reserved.