Generation of induced pluripotent stem cell line (ZZUi028-A) from a 52-year-old Chinese Han healthy female individual
Generation of induced pluripotent stem cell line (ZZUi028-A) from a 52-year-old Chinese Han healthy female individual
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52岁中国汉族健康女性诱导多能干细胞系（ZZUi028-A）的产生
DOI：
10.1016/j.scr.2021.102381
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发表时间：
2021
影响因子：
1.2
通讯作者：
Xu Yuming
中科院分区：
文献类型：
--
作者：
Wang Yanlin;Wang Zhuoya;Sun Huifang;Zhang Qi;Yang Jing;Liu Yutao;Liu Han;Shi Changhe;Zhang Rui;Xu Yuming
皮肤成纤维细胞由一位52岁的健康汉族妇女捐赠。诱导多能干细胞(IPSC)系的构建使用了一种使所产生的IPSC不整合的附体重编程方法。该IPSC系表达常见的多能标记，可分化为三个胚层，体内核型正常。IPSC可用于产生不同类型的细胞，可作为药物开发和病理机制研究的对照。
Skin fibroblasts were donated by a healthy 52-year-old Han Chinese woman. The induced pluripotent stem cell (iPSC) line was constructed using an episomal reprogramming method that made the generated iPSCs integration-free. This iPSC line expressed the common pluripotency markers, could be differentiated into three germ layers, and showed normal karyotypein vivo. The iPSC line can be used to generate different cell types, which could be used as a control in drug development and studies on pathological mechanisms.