Carbohydrate metabolism of the liver in normal man under varying dietary conditions.
Carbohydrate metabolism of the liver in normal man under varying dietary conditions.
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正常人在不同饮食条件下肝脏的碳水化合物代谢。
DOI：
10.3109/00365517309084356
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发表时间：
1973
影响因子：
2.1
通讯作者：
E. Hultman
中科院分区：
文献类型：
--
作者：
L. Nilsson;P. Fürst;E. Hultman
在两组健康受试者中，采用肝静脉导管插入技术，在摄入明确的正常热量饮食4天后，测量葡萄糖和尿素的产生以及肝脏对致炎前体的摄取。在正常混合饮食后，净内脏葡萄糖产生为0.87 mmol/min。来自最大再生的葡萄糖为0.31 mmol/min。通过使用类似系列的肝活检技术，糖原分解为0.54 mmol葡萄糖/min。在碳水化合物贫乏的饮食后，内脏葡萄糖产生降低至0.30 mmol/min。在这种情况下，肝脏被剥夺了大部分的糖原，如前所述，直接测定肝活检标本中的糖原。代谢底物的摄取对应于净葡萄糖产量。低碳水化合物饮食期间葡萄糖产生的减少并没有导致血糖水平的任何显著变化。这表明，外周摄取的显着减少…
The glucose and urea production and the uptake of gluconeogenic precursors by the liver were measured with the liver vein catheterization technique in two series of healthy subjects after 4 days on a well-defined normo-caloric diet. After a normal mixed diet the net splanchnic glucose production was 0.87 mmol/min. The glucose derived from maximum gluconeogenesis was 0.31 mmol/min. By using a liver biopsy technique in a similar series, the glycogenolysis was found to be 0.54 mmol glucose/min. After a carbohydrate-poor diet the splanchnic glucose production had decreased to 0.30 mmol/min. In this situation the liver was deprived of most of its glycogen, as shown earlier by direct determination of glycogen in liver biopsy specimens. The uptake of gluconeogenic substrates corresponded to the net glucose production. The decreased glucose production during carbohydrate-poor diet did not result in any significant change of the blood glucose level. This indicates a considerable decrease of the peripheral uptake o...