Rapid decline in lung function in healthy adults predicts incident excess urinary albumin excretion later in life.
Rapid decline in lung function in healthy adults predicts incident excess urinary albumin excretion later in life.
复制标题
健康成年人肺功能的迅速下降预示着晚年会出现尿白蛋白排泄过多的情况。
DOI：
10.1136/bmjresp-2017-000194
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发表时间：
2017
影响因子：
4.1
通讯作者：
Sood,Akshay
中科院分区：
文献类型：
--
作者：
Bhatia,Sapna;Qualls,Clifford;Crowell,ThomasA;Arynchyn,Alexander;Thyagarajan,Bharat;Smith,LewisJ;Kalhan,Ravi;Jacobs,DavidR;Kramer,Holly;Duprez,Daniel;Celli,Bartolome;Sood,Akshay
IntroductionChronic lung disease, often characterised by rapid decline in lung function, is associated with vascular endothelial dysfunction (characterised by moderate to severe excess urinary albumin excretion (eUAE) but their longitudinal relationship is inadequately studied. In a bidirectional longitudinal examination of healthy adults, we analysed the following two hypotheses: (1) rapid decline (ie, highest tertile of lung function decline) predicts eUAE and (2) eUAE predicts rapid decline.MethodsWe performed a secondary data analysis from 3052 eligible participants from the Coronary Artery Risk Development in Young Adults (CARDIA) study. For analysis 1, the predictor was rapid decline in lung function between the peak value (attained at or before CARDIA visit year 10 or Y10 at a mean age of 35 years) and Y20; and the outcome was incident eUAE at Y20 and/or Y25. For analysis 2, the predictor was eUAE at Y10 and the outcome was rapid decline between Y10 and Y20.ResultsAfter adjustment for covariates in analysis 1, rapid decline in FEV1or FVC between peak and Y20 predicted incident eUAE at Y20 and/or Y25 (OR 1.51 and 1.44, respectively; p≤0.05 for both analyses). In analysis 2, eUAE at Y10 did not predict subsequent rapid decline.ConclusionsHealthy adults with rapid decline in lung function are at risk for developing vascular endothelial dysfunction, as assessed by incident eUAE, later in life.
