Self-Directed Home-Based Dim-Light Melatonin Onset Collection: The Circadia Pilot Study.
Self-Directed Home-Based Dim-Light Melatonin Onset Collection: The Circadia Pilot Study.
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自我指导的家庭微光褪黑激素发作系列：昼夜节律试点研究。
DOI：
10.1101/2023.05.26.23290467
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Lane,JacquelineM
中科院分区：
文献类型：
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作者：
Bormes,Gregory;Love,Jessica;Akeju,Oluwaseun;Cherry,Jakob;Kunorozva,Lovemore;Qadri,Salim;Rahman,ShadabA;Westover,Brandon;Winkelman,John;Lane,JacquelineM
研究目的测试一种新的在家唾液昏暗光褪黑激素发作（DLMO）评估方案的可行性，以测量10个个体（1个晚期睡眠-觉醒相障碍患者（ASWPD），4个延迟睡眠-觉醒相障碍患者（DSWPD）和5个对照）的内源性昼夜节律时相。方法10例受试者（男1例，女9例），年龄27 ~ 63岁，平均38岁。我们的研究人群包括7名被确定为白色的个体和3名被确定为亚洲的个体。我们的参与者在性别认同方面是多样化的（女性= 7，男性= 1，变性人= 1，非二元= 1，无= 1）。该研究使用自我报告的在线睡眠日记和客观的活动记录数据跟踪了10个人在5-6周内的睡眠和活动模式。参与者完成了两个自我导向的DLMO评估，大约间隔一周，坚持客观的合规措施。参与者完全远程完成了这项研究：他们在线完成了所有的睡眠日记和其他评估，并邮寄了一个工具包，其中包含进行活动记录和在家样本收集所需的所有材料。结果用Hockeystick法计算了8/10例受试者的唾液DLMO时间。DLMO时间平均比自我报告的睡眠开始时间早3小时18分钟（DSPD：12：04 AM，对照组：9：55 PM）。在我们计算了两个单独DLMO时间的6名参与者中，DLMO 1和2的相关性为96%（p<0.0005）。结论我们的研究结果表明，自我导向，在家里DLMO评估是可行的和准确的。目前的协议可以作为一个框架，以可靠地评估昼夜节律阶段在临床和一般人群。
Study Objectives To test the feasibility of a novel at-home salivary Dim Light Melatonin Onset (DLMO) assessment protocol to measure the endogenous circadian phase of 10 individuals ( 1 Advanced Sleep-Wake Phase Disorder patient (ASWPD), 4 Delayed Sleep-Wake Phase Disorder patients (DSWPD), and 5 controls). Methods The study involved 10 participants (sex at birth: females = 9; male= 1), who ranged between 27 to 63 years old, with an average age of 38 years old. Our study population consisted of 7 individuals who identified as white and 3 who identified as Asian. Our participants were diverse in gender identity (woman = 7, male = 1, transgender = 1, nonbinary = 1, none = 1).The study tracked the sleep and activity patterns of 10 individuals over a 5–6 week period using self-reported online sleep diaries and objective actigraphy data. Participants completed two self-directed DLMO assessments, approximately one week apart, adhering to objective compliance measures. Participants completed the study entirely remotely: they completed all sleep diaries and other evaluations online and were mailed a kit with all materials needed to perform the actigraphy and at-home sample collections. Results Salivary DLMO times were calculated for 8/10 participants using the Hockeystick method. DLMO times were on average 3 hours and 18 minutes earlier than self-reported sleep onset times (DSPD: 12:04 AM, controls: 9:55 PM.) Among the 6 participants for whom we calculated two separate DLMO times, DLMOs 1 and 2 were 96% correlated (p<0.0005.) Conclusions Our results indicate that self-directed, at-home DLMO assessments are feasible and accurate. The current protocol may serve as a framework to reliably assess circadian phase in both clinical and general populations.