Working memory-based and -free reward prediction in a dual dopamine system in the basal ganglia
Working memory-based and -free reward prediction in a dual dopamine system in the basal ganglia
复制标题
DOI：
10.1101/2023.03.06.531239
复制
发表时间：
2023-03
期刊：
影响因子：
--
通讯作者：
Tomohiko Yoshizawa;Yuuto Miyamura;Yuta Ochi;R. Hira;M. Funahashi;Y. Sakai;Yilong Cui;Y. Isomura
中科院分区：
文献类型：
--
作者：
Tomohiko Yoshizawa;Yuuto Miyamura;Yuta Ochi;R. Hira;M. Funahashi;Y. Sakai;Yilong Cui;Y. Isomura
动物通过预测和验证它们的结果来优化它们的行为（例如，奖励）。奖励预测通常需要基于工作记忆（WM）的信息。为了阐明基于WM的奖励预测的神经基础，我们比较了大鼠和小鼠腹侧被盖区（VTA）多巴胺（DA）神经元在交替奖励条件（基于WM）和随机奖励条件（无WM）下的活动。正电子发射断层扫描显示更大的腹侧被盖区激活的WM为基础的WM比无条件。外侧和内侧腹侧被盖区神经元表现出不同的电生理尖峰活动，分别反映了基于WM和无WM的奖励预测误差。此外，在背侧和腹侧纹状体的阶段性DA释放的变化WM为基础的和WM自由经典条件反射的进展。与我们基于WM的模型一致，奖励获取仅导致背侧纹状体的DA下降。因此，双DA系统并行处理基于WM和无WM的奖励预测。
Animals optimize their actions by predicting and verifying their outcomes (e.g., rewards). Reward prediction often requires working memory (WM)-based information. To elucidate the neural basis of WM-based reward prediction, we compared the activity of dopamine (DA) neurons in the ventral tegmental area (VTA) in an alternate reward condition (WM-based) with that in a random (WM-free) reward condition in rats and mice. Positron emission tomography revealed greater VTA activation in the WM-based than the WM-free condition. Lateral and medial VTA neurons displayed differential electrophysiological spike activities reflecting WM-based and WM-free reward prediction error, respectively. Furthermore, phasic DA release in the dorsal and ventral striatum changed as WM-based and WM-free classical conditioning progressed. Consistent with our WM-based model, reward acquisition caused a DA dip only in the dorsal striatum. Thus a dual DA system processes WM-based and WM-free reward prediction in parallel.