PARTICIPATION OF A NONENZYMATIC TRANSFORMATION IN BIOSYNTHESIS OF ESTROGENS FROM ANDROGENS
PARTICIPATION OF A NONENZYMATIC TRANSFORMATION IN BIOSYNTHESIS OF ESTROGENS FROM ANDROGENS
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DOI：
10.1126/science.831259
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发表时间：
1977-01-01
期刊：
影响因子：
56.9
通讯作者：
FISHMAN, J
中科院分区：
文献类型：
--
作者：
GOTO, J;FISHMAN, J
从雄激素生物合成雌激素通过三种酶促羟基化进行，其中前两种发生在C-19甲基上并将其转化为醛。最终的和速率决定性的羟基化发生在2β位，产物迅速非酶降解为雌激素。
The biosynthesis of estrogens from androgens proceeds via three enzymatic hydroxylations, of which the first two take place on the C-19 methyl group and convert it to aldehyde. The final and rate-determining hydroxylation occurs at the 2β position, and the product rapidly and nonenzymatically collapses to an estrogen.