Rectal microbicides for US gay men -: Are clinical trials needed?: Are they feasible?
Rectal microbicides for US gay men -: Are clinical trials needed?: Are they feasible?
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DOI：
10.1097/00007435-199807000-00005
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发表时间：
1998-07-01
影响因子：
3.1
通讯作者：
Seage, GR
中科院分区：
文献类型：
--
作者：
Gross, M;Buchbinder, SP;Seage, GR
背景和目的：男同性恋者肛交时不完全使用安全套的情况持续存在;杀微生物剂可能提供额外的保护。尽管缺乏有效性或安全性数据，许多男同性恋者使用含有壬苯醇醚-9（N-9）的性润滑剂，这是一种基于洗涤剂的杀精剂，正在评估其作为阴道杀微生物剂的有效性。目标：评估六个城市中高危人类免疫缺陷病毒（HIV）血清阴性的美国男同性恋者的无保护性行为、润滑剂使用情况以及对可能参与直肠杀微生物剂临床试验的态度。
Background and Objectives: Incomplete condom use during anal sex persists among gay men; microbicides may provide additional protection. Despite the absence of efficacy or safety data, many gay men use sexual lubricants containing nonoxynol-9 (N-9), a detergent-based spermicide under evaluation for efficacy as a vaginal microbicide.Goal: Evaluate unprotected sex, lubricant use, and attitudes regarding possible participation in clinical trials of rectal microbicides among high-risk human immunodeficiency virus(HIV) seronegative U.S. gay men in six cities.