Flexible and bendable acoustofluidics for particle and cell patterning
Flexible and bendable acoustofluidics for particle and cell patterning
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DOI：
10.1016/j.ijmecsci.2021.106536
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发表时间：
2021-05-29
影响因子：
7.3
通讯作者：
Fu, Yongqing
中科院分区：
文献类型：
--
作者：
Maramizonouz, Sadaf;Tao, Xiang;Fu, Yongqing
基于表面声波（SAW）的微流控器件提供了操纵流体和颗粒的主动技术，其可以用于以非侵入性和非接触方式高效率地精确和可控地图案化微粒和生物细胞。本文研究了柔性和可弯曲的SAW微流体器件，并探讨了SAW器件的弯曲和扭曲对微粒和细胞图案化的影响，使用实验和数值模拟。我们发现，弯曲的柔性SAW器件的粒子图案线的分布发生了显着的变化。在具有凹弯曲的器件中，颗粒图案线朝向曲率中心会聚，而对于具有凸弯曲的器件，颗粒图案线远离曲率中心发散。比较使用具有凹弯曲的兰姆波和瑞利波器件的颗粒图案化，我们发现，颗粒对准在弯曲模式兰姆波器件中更有效，而对于具有凸弯曲的器件，当使用瑞利波时，颗粒图案更加清晰和规则。我们进一步研究了扭曲的柔性SAW器件的影响，并观察到，颗粒图案化为平行于变形叉指换能器（IDT）的线。我们最终使用我们的柔性SAW器件对酵母细胞进行了图案化，并证明了将我们的柔性声流体器件用于生物力学系统的可能性，例如身体顺应技术，可穿戴生物传感器和用于个性化健康监测的柔性即时护理设备。
Surface Acoustic Wave (SAW) based microfluidic devices provide active techniques to manipulate fluid and particles, which can be used for precise and controllable patterning of microparticles and biological cells, with a high efficiency in a non-invasive and contact-free manner. This paper investigates flexible and bendable SAW microfluidic devices and explores the effects of bending and twisting of SAW devices on microparticle and cell patterning, using both experimental and numerical modelling. We showed that bending flexible SAW devices changes the distribution of particle pattern lines significantly. In devices with concave bending the particle pattern lines converge towards the centre of the curvature, whereas for devices with convex bending, they diverge away from it. Comparing the particle patterning using Lamb and Rayleigh wave devices with concave bending, we found that particle alignment is more efficient in the flexural mode Lamb wave device, whereas for the devices with convex bending, the particle patterning is more clear and regular when Rayleigh waves are used. We further investigated the effects of twisting the flexible SAW devices and observed that the particles are patterned into lines parallel to the deformed interdigital transducers (IDTs). We finally patterned yeast cells using our flexible SAW devices, and demonstrated the possibility of using our flexible acoustofluidic device for biomechanical systems such as body conforming technologies, wearable bio-sensors, and flexible point-of-care devices for personalized health monitoring.