Angiotensin-converting Enzyme I/D Polymorphism is Associated with COPD Risk in Asian Population: Evidence from a Meta-analysis
Angiotensin-converting Enzyme I/D Polymorphism is Associated with COPD Risk in Asian Population: Evidence from a Meta-analysis
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DOI：
10.3109/15412555.2012.727047
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发表时间：
2013-02-01
影响因子：
2.2
通讯作者：
Shen, Huahao
中科院分区：
文献类型：
--
作者：
Li, Wen;Lan, Fen;Shen, Huahao
近年来，一些分子流行病学研究探讨了血管紧张素转换酶（ACE）基因插入/缺失（I/D）多态性与慢性阻塞性肺疾病（COPD）发病的关系。然而，结果仍然相互矛盾，而不是结论性的。为了更精确地评估ACE基因多态性与COPD风险之间的关系，我们对所有相关研究进行了荟萃分析。我们使用比值比（OR）和95%置信区间（CI）来评估相关性的强度。在亚洲人中，D等位基因或DD基因型与COPD风险显著正相关（D vs. I：OR = 1.55，95% CI = 1.407-2.44; DD vs. II：OR = 2.53，95% CI = 1.65-3.89; DD vs. DI/II：OR = 2.09，95%CI = 1.09-4.03），但在欧洲人中未观察到这种相关性（D与I：OR = 0.93，95%CI = 0.75-1.15; DD与II：OR = 0.86，95%CI = 0.56-1.33; DD与DI/II：OR = 0.88，95%CI = 0.63-1.23）。我们的荟萃分析提供了强有力的证据，D等位基因和DD纯合子可能是亚洲人COPD易感性的重要遗传分子标记，而不是欧洲人。我们的结果的验证需要额外的精心设计的大型研究。
Several molecular epidemiological studies were conducted in recent years to evaluate the risk of chronic obstructive pulmonary disease (COPD) associated with insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE). However, the results remain conflicting rather than conclusive. To derive a more precise estimation of association between ACE polymorphism and the risk of COPD, we performed a meta-analysis from all available relevant studies. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. There was a markedly positive association between the D allele or DD genotype and COPD risk in Asians (D vs. I: OR = 1.55, 95% CI = 1.407-2.44; DD vs. II: OR = 2.53, 95% CI = 1.65-3.89; DD vs. DI/II: OR = 2.09, 95% CI = 1.09-4.03), but this association was not observed in Europeans (D vs. I: OR = 0.93, 95% CI = 0.75-1.15; DD vs. II: OR = 0.86, 95% CI = 0.56-1.33; DD vs. DI/II: OR = 0.88, 95% CI = 0.63-1.23). Our meta-analysis provides strong evidence that D allele and DD homozygous might be significant genetic molecular markers for COPD susceptibility in Asians, but not for Europeans. Additional well-designed large studies were required for the validation of our results.