Exploring the native human antibody repertoire to create antiviral therapeutics.
Exploring the native human antibody repertoire to create antiviral therapeutics.
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探索天然人类抗体库以创造抗病毒疗法。
DOI：
10.1007/978-3-540-72146-8_6
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发表时间：
2008
影响因子：
--
通讯作者：
Berry,JD
中科院分区：
文献类型：
--
作者：
Dessain,SK;Adekar,SP;Berry,JD
天然人抗体定义为由于完整的人免疫系统的功能而天然产生的那些抗体。天然抗体用于治疗人类病毒性疾病的效用已经通过超免疫人类球蛋白的经验建立。天然抗体作为一类，在某些方面不同于通过重组文库方法（噬菌体或转基因小鼠）获得的那些抗体，并且具有可使它们成为人类病毒性疾病的理想治疗剂的独特性质。克隆天然人抗体的方法一直受到技术问题的困扰，然而已经克隆了许多对病毒抗原特异性的抗体。在本综述中，我们讨论了天然人抗体和克隆方法的持续改进，这将有助于从天然人抗体库中获得新型、有效的抗病毒疗法。
Native human antibodies are defined as those that arise naturally as the result of the functioning of an intact human immune system. The utility of native antibodies for the treatment of human viral diseases has been established through experience with hyperimmune human globulins. Native antibodies, as a class, differ in some respects from those obtained by recombinant library methods (phage or transgenic mouse) and possess distinct properties that may make them ideal therapeutics for human viral diseases. Methods for cloning native human antibodies have been beset by technical problems, yet many antibodies specific for viral antigens have been cloned. In the present review, we discuss native human antibodies and ongoing improvements in cloning methods that should facilitate the creation of novel, potent antiviral therapeutics obtained from the native human antibody repertoire.