Molecular mechanism of Streptococcus pneumoniae targeting xenophagy recognition and evasion: Reinterpretation of pneumococci as intracellular bacteria
Molecular mechanism of Streptococcus pneumoniae targeting xenophagy recognition and evasion: Reinterpretation of pneumococci as intracellular bacteria
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肺炎链球菌靶向异体吞噬识别和逃避的分子机制：肺炎球菌作为细胞内细菌的重新解释
DOI：
10.1111/1348-0421.13060
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发表时间：
2023
影响因子：
2.6
通讯作者：
Ohnishi Makoto
中科院分区：
文献类型：
--
作者：
Ogawa Michinaga;Shizukuishi Sayaka;Akeda Yukihiro;Ohnishi Makoto
肺炎链球菌是一种主要的革兰氏阳性病原体，可引起包括社区获得性肺炎、脑膜炎和败血症在内的疾病。这种病原体无症状地定植于鼻咽上皮，但通常可迁移至无菌组织并引起危及生命的侵入性感染（侵入性肺炎球菌病）。虽然多价肺炎球菌多糖和结合疫苗是可用的并且有效，但是它们在疫苗耐药血清型的出现方面也具有主要缺点。因此，需要替代的治疗方法，宿主-病原体相互作用的分子分析及其在药物开发和临床实践中的应用最近受到越来越多的关注。在这篇综述中，我们介绍了肺炎球菌的表面毒力因子参与致病性，并强调了最近的进展，我们的理解宿主自噬识别机制对intracellularS。肺炎球菌和肺炎球菌逃避自噬。
Streptococcus pneumoniaeis a major, encapsulated Gram‐positive pathogen that causes diseases including community‐acquired pneumonia, meningitis, and sepsis. This pathogen colonizes the nasopharyngeal epithelia asymptomatically but can often migrate to sterile tissues and cause life‐threatening invasive infections (invasive pneumococcal disease). Although multivalent pneumococcal polysaccharides and conjugate vaccines are available and effective, they also have major shortcomings with respect to the emergence of vaccine‐resistant serotypes. Therefore, alternative therapeutic approaches are needed, and the molecular analysis of host–pathogen interactions and their applications to pharmaceutical development and clinical practice has recently received increased attention. In this review, we introduce pneumococcal surface virulence factors involved in pathogenicity and highlight recent advances in our understanding of host autophagy recognition mechanisms against intracellularS. pneumoniaeand pneumococcal evasion from autophagy.