The melanoma revolution: from UV carcinogenesis to a new era in therapeutics.
The melanoma revolution: from UV carcinogenesis to a new era in therapeutics.
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DOI：
10.1126/science.1253735
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发表时间：
2014-11-21
期刊：
影响因子：
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通讯作者：
Fisher DE
中科院分区：
文献类型：
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作者：
Lo JA;Fisher DE
黑色素瘤是最致命的皮肤癌，是一种发病率不断上升的侵袭性疾病。虽然黑色素瘤是一种历史上难治的恶性肿瘤，但近年来靶向治疗和免疫治疗的前所未有的突破彻底改变了晚期疾病患者的护理标准。在这里，我们提供了一个概述，我们在黑色素瘤的危险因素，基因组学和分子发病机制的理解，以及这些见解如何推动黑色素瘤治疗的进展的最新进展。此外，我们回顾了目前治疗的益处和局限性，并展望了黑色素瘤预防和治疗的持续进展。该领域的显着成就已经在黑色素瘤治疗中产生了范式转变-转移性黑色素瘤，曾经被认为是不可治愈的，现在可以用潜在的治愈而不是姑息治疗。
Melanoma, the deadliest form of skin cancer, is an aggressive disease that is rising in incidence. Although melanoma is a historically treatment-resistant malignancy, in recent years unprecedented breakthroughs in targeted therapies and immunotherapies have revolutionized the standard of care for patients with advanced disease. Here we provide an overview of recent developments in our understanding of melanoma risk factors, genomics, and molecular pathogenesis and how these insights have driven advances in melanoma treatment. In addition, we review benefits and limitations of current therapies and look ahead to continued progress in melanoma prevention and therapy. Remarkable achievements in the field have already produced a paradigm shift in melanoma treatment – metastatic melanoma, once considered incurable, can now be treated with potentially curative rather than palliative intent.