HMB‐45 Staining of Dysplastic Nevi: Support for a Spectrum of Progression Toward Melanoma
HMB‐45 Staining of Dysplastic Nevi: Support for a Spectrum of Progression Toward Melanoma
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发育不良痣的 HMB-45 染色：支持黑色素瘤的进展谱
DOI：
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发表时间：
1989
影响因子：
5.6
通讯作者：
Amy T. Hsu
中科院分区：
文献类型：
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作者：
B. Smoller;N. McNutt;Amy T. Hsu
发育不良痣是黑素细胞肿瘤，在黑素细胞增殖谱中占据中间位置。虽然如果完全切除，它们总是可以治愈，但如果不治疗，它们的生物学潜力是未知的。我们用HMB-45（一种黑素细胞特异性抗体）检查了一系列此类病变，以探讨这些边界病变内的蛋白质表达。HMB-45先前已显示标记黑色素瘤和所有痣内的表皮内黑色素细胞。皮内黑色素瘤细胞也用HMB-45标记，但普通黑色素细胞痣内的真皮痣细胞通常不染色。与此相反，我们发现轻度至中度染色的痣细胞内的乳头状真皮的发育不良痣和残余痣细胞内邻近恶性黑色素瘤。在相同的病变，我们表现出强染色的表皮内黑色素细胞。因此，发育不良痣内的真皮痣细胞和与恶性黑色素瘤相邻的残留痣细胞内的真皮痣细胞表达由黑色素瘤细胞表达的低水平量的蛋白质，但不表达由完全良性黑色素细胞肿瘤内的真皮痣细胞表达的蛋白质。这支持了这些病变作为生物学潜能未确定的前驱病变的概念。
Dysplastic nevi are melanocytic tumors that occupy intermediate positions in the spectrum of melanocytic proliferations. Although they are invariably cured if completely excised, their biologic potential if left untreated is unknown. We examined a series of such lesions with HMB-45, a melanocyte-specific antibody, in order to explore protein expression within these borderline lesions. HMB-45 has previously been shown to label intraepidermal melanocytes within melanomas and within all nevi. Intradermal melanoma cells also label with HMB-45, but dermal nevus cells within common melanocytic nevi do not normally stain. In contrast, we found mild to moderate staining of nevus cells within the papillary dermis of dysplastic nevi and within residual nevus cells adjacent to malignant melanomas. In the same lesions, we demonstrated strong staining of intraepidermal melanocytes. Thus, dermal nevus cells within dysplastic nevi and within residual nevus cells adjacent to malignant melanomas are expressing low-level amounts of a protein expressed by melanoma cells, but not by dermal nevus cells within wholly benign melanocytic tumors. This lends support to the concept of these lesions as precursor lesions with undetermined biologic potential.