A novel action of the newly described prolactin-releasing peptides: cardiovascular regulation
A novel action of the newly described prolactin-releasing peptides: cardiovascular regulation
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新描述的催乳素释放肽的新作用：心血管调节
DOI：
10.1016/s0006-8993(99)02451-8
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发表时间：
2000
期刊：
影响因子：
2.9
通讯作者：
T. Murphy
中科院分区：
文献类型：
--
作者：
W. Samson;Zachary T. Resch;T. Murphy
最近描述的催乳素释放肽（PrRPs）的生理相关性尚未建立。在这里，我们证明了低效力的PrRPs（最小有效剂量：100 nM）相比，观察到促甲状腺激素释放激素（TRH，最小有效剂量：1.0 nM），刺激催乳素（PRL）释放从培养的垂体细胞收获的哺乳期雌性大鼠。解剖学研究质疑这些肽在神经内分泌控制催乳素功能中的作用。相反，肽和肽受体作图研究表明，下丘脑和脑干的潜在作用与垂体前叶激素分泌的控制无关。脑室内（i. c. v.）PrRP-20和PrRP-31（0.4和4.0 nmol）的给药导致清醒的、不受约束的大鼠的平均动脉血压显著升高[峰值升高相对于基线：PrRP-20，10%和16%，低剂量和高剂量肽; PrRP-31，7%和10%;与对0.1 nmol血管紧张素II（A II）的反应相比，15-17%]。相似剂量的肽没有显著改变响应于过夜流体剥夺的饮水，或响应于等渗低血容量挑战的口渴或盐食欲。因此，对血压的影响似乎相对特异。我们认为，这些肽，最初被确定为在脑垂体中发现丰富的受体的配体，在脑功能中发挥更广泛的作用，它们刺激PRL释放的能力可能并不代表其主要的生物学功能。
The physiological relevance of the recently described prolactin-releasing peptides (PrRPs) has yet to be established. Here, we demonstrate the low potency of the PrRPs (minimum effective dose: 100 nM), compared to that observed for thyrotropin-releasing hormone (TRH, minimum effective dose: 1.0 nM), to stimulate prolactin (PRL) release from cultured pituitary cells harvested from lactating female rats. Anatomic studies question the role of these peptides in neuroendocrine control of lactotroph function. Instead, peptide and peptide receptor mapping studies suggest potential actions in hypothalamus and brainstem unrelated to the control of anterior pituitary hormone secretion. Intracerebroventricular (i.c.v.) administration of both PrRP-20 and PrRP-31 (0.4 and 4.0 nmol) resulted in significantly increased mean arterial blood pressure in conscious, unrestrained rats [peak elevations vs. baseline: PrRP-20, 10% and 16%, low and high dose peptide; PrRP-31, 7% and 10%; compared to the response to 0.1 nmol angiotensin II (A II), 15–17%]. Similar doses of peptide did not significantly alter water drinking in response to overnight fluid deprivation, or thirst or salt appetite in response to an isotonic hypovolemic challenge. Thus, the effect on blood pressure appeared relatively specific. We suggest that these peptides, identified originally as ligands for a receptor found in abundance in pituitary gland, play a broader role in brain function and that the ability of them to stimulate PRL release may not represent their primary biologic function.
血管活性肠肽是大鼠催乳素释放的生理介质。
影响因子：
4.8
作者：
Abe,H;Engler,D;Molitch,ME;Bollinger-Gruber,J;Reichlin,S
通讯作者：
Reichlin,S
转基因小鼠中叶肿瘤中两类催乳素释放因子的鉴定。
DOI：
10.1210/endo.136.7.7789336
发表时间：
1995
期刊：
Endocrinology.
影响因子：
--
作者：
Allen,DL;Low,MJ;Allen,RG;Ben-Jonathan,N
通讯作者：
Ben-Jonathan,N