A preliminary study on the effect of combined nicotine replacement therapy on alcohol responses and alcohol self-administration.
A preliminary study on the effect of combined nicotine replacement therapy on alcohol responses and alcohol self-administration.
复制标题
联合尼古丁替代疗法对酒精反应和酒精自我给药影响的初步研究。
DOI：
10.1111/j.1521-0391.2013.12014.x
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
McKee,SherryA
中科院分区：
文献类型：
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作者：
Udo,Tomoko;Harrison,EmilyLR;Shi,Julia;Tetrault,Jeanette;McKee,SherryA
背景和目的限制饮酒可能有助于预防重度饮酒吸烟者酒精介导的吸烟复发。这项初步研究探讨了尼古丁贴片与尼古丁鼻喷雾剂相结合是否比尼古丁贴片单独使用对酒精反应和消耗有更强的衰减作用。MethodsTwenty‐ 2个非酒精依赖的重度饮酒吸烟者完成了双盲交叉安慰剂对照研究（21 mg尼古丁贴片+尼古丁或安慰剂鼻喷雾剂）。在21 mg尼古丁贴片贴敷后6小时，评估了对预激饮料（0.3 g/kg）的主观和生理反应，随后是两个1小时的酒精自我给药期，每个阶段最多可饮酒4次（每次0.15 g/kg）。鼻喷雾剂（1毫克[活性]或0毫克[安慰剂]每剂量）前10分钟的启动剂量和每个自我管理period.ResultsActive鼻喷雾剂不增加血清尼古丁水平，与安慰剂给药相比。饮用的饮料数量没有因鼻喷雾条件而异。然而，积极的主观反应，以启动饮料是较低的积极鼻喷雾条件比安慰剂鼻喷雾条件。在自我给药期间，主动喷雾条件下的饮酒欲望也低于安慰剂condition.Conclusions and Scientific SignificanceAugmenting尼古丁贴片与尼古丁鼻喷雾衰减积极的主观酒精反应和渴望，并建议未来的研究应调查这些发现是否转化为临床环境。(Am J Addict 2013;22：590-597）
Background and ObjectivesLimiting alcohol consumption may help prevent alcohol‐mediated smoking relapse in heavy drinking smokers. This pilot study examined whether combining a nicotine patch with nicotine nasal spray has stronger attenuating effects on alcohol response and consumption than a nicotine patch alone.MethodsTwenty‐two non‐alcohol dependent heavy drinking smokers completed the double‐blind cross‐over, placebo‐controlled study (21 mg nicotine patch+nicotine or placebo nasal spray). Six hours after 21mg nicotine patch application, subjective and physiological responses to a priming drink (0.3 g/kg) were assessed, followed by two 1‐hr alcohol self‐administration periods, with possible consumption of up to 4 drinks per period (each 0.15 g/kg). Nasal spray (1 mg [active] or 0 mg [placebo] per dose) was administered 10 min prior to the priming dose and each self‐administration period.ResultsActive nasal spray did not increase serum nicotine levels, compared with placebo administration. The number of drinks consumed did not differ by the nasal spray conditions. However, positive subjective responses to the priming drink were lower in the active nasal spray condition than the placebo nasal spray condition. During the self‐administration period, urge to drink was also lower in the active spray condition than the placebo condition.Conclusions and Scientific SignificanceAugmenting the nicotine patch with nicotine nasal spray attenuated positive subjective alcohol response and craving and suggests that future studies should investigate whether these findings translate to a clinical setting. (Am J Addict 2013;22:590–597)