Cross-couplings of alkyl electrophiles under "ligandless" conditions: Negishi reactions of organozirconium reagents
Cross-couplings of alkyl electrophiles under "ligandless" conditions: Negishi reactions of organozirconium reagents
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DOI：
10.1021/ja0393729
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发表时间：
2004-01-14
影响因子：
15
通讯作者：
Fu, GC
中科院分区：
文献类型：
--
作者：
Wiskur, SL;Korte, A;Fu, GC
本报告建立了简单的，“无配体”钯配合物可以催化烷基亲电试剂的第一个锆Negishi反应。考虑到无配体催化剂的吸引力（成本、简单性和易于纯化），这些观察结果为开发用于偶联烷基亲电试剂的有效钯基方法增加了一个重要且有趣的新维度。
This report establishes that simple, “ligandless” palladium complexes can catalyze the first zirconium-Negishi reactions of alkyl electrophiles. In view of the attractiveness of ligandless catalysts (cost, simplicity, and ease of purification), these observations add a significant and intriguing new dimension to the development of effective palladium-based processes for coupling alkyl electrophiles.