The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells.
The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells.
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DOI：
10.3389/fimmu.2017.00480
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发表时间：
2017
影响因子：
7.3
通讯作者：
Leo O
中科院分区：
文献类型：
--
作者：
Andris F;Denanglaire S;Anciaux M;Hercor M;Hussein H;Leo O
滤泡辅助性T细胞（Tfh）已被确定为调节生发中心B细胞反应的主要细胞亚群，从而支持高亲和力抗体的产生。在调节Tfh细胞分化和功能的转录因子中，原癌基因c-Maf所起的作用仍然知之甚少。我们在此报道，T细胞室中c-Maf表达的选择性缺失导致Tfh细胞在抗原/佐剂疫苗接种和共生肠道细菌应答中发育缺陷。因此，c-Maf在T细胞中的表达对于免疫动物的发育和高亲和力抗体的分泌至关重要。c-Maf与BCL6一起在Tfh细胞前体中早期表达，并以细胞自主的方式调节Tfh的命运。总之，我们的研究结果揭示了c-Maf在Tfh细胞分化和对t细胞依赖性抗原的体液免疫反应的调节中的一种新的、非冗余的功能。
Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production. Among the transcription factors orchestrating Tfh cell differentiation and function, the role played by the proto-oncogene c-Maf remains poorly characterized. We report herein that selective loss of c-Maf expression in the T cell compartment results in defective development of Tfh cells in response to both antigen/adjuvant vaccinations and commensal intestinal bacteria. Accordingly, c-Maf expression in T cells was essential for the development and high-affinity antibody secretion in vaccinated animals. c-Maf was expressed early, concomitantly to BCL6, in Tfh cell precursors and found to regulate Tfh fate in a cell-autonomous fashion. Altogether, our findings reveal a novel, non-redundant, function for c-Maf in the differentiation of Tfh cells and the regulation of humoral immune responses to T-cell-dependent antigens.