Evaluation of transcatheter heart valve biomaterials: Computational modeling using bovine and porcine pericardium.
Evaluation of transcatheter heart valve biomaterials: Computational modeling using bovine and porcine pericardium.
复制标题
经导管心脏瓣膜生物材料的评估：使用牛和猪心包的计算模型。
DOI：
10.1016/j.jmbbm.2019.05.020
复制
发表时间：
2019
影响因子：
3.9
通讯作者：
Sun,Wei
中科院分区：
文献类型：
--
作者：
Sulejmani,Fatiesa;Caballero,Andrés;Martin,Caitlin;Pham,Thuy;Sun,Wei
目的采用牛（BP）和猪（PP）心包组织制成的生物人工心脏瓣膜（BHV）装置，其耐久性部分受到装置钙化和组织变性的限制，而这些组织变性与病理水平的机械应力有关。本研究探讨了不同厚度的BP和PP组织及其力学性能在BHV应用中的影响。方法采用二次谐波成像（SHG）对心包两侧的胶原纤维进行成像。采用多光子显微镜对每种组织类型进行胶原纤维分布的结构本构建模，以表征先前研究中收集的相应的双轴力学测试数据。通过双轴试验的有限元仿真验证了模型的正确性，并将其应用于阀门关闭仿真中。结果光滑侧胶原纤维与力学反应相关。成人（ABP）和小牛（CBP） BP组织的bhv最大主应力低于PP和胎儿（FBP） BP组织的bhv。胶原纤维沿周向取向导致最大主应力较低，整个瓣膜的应力分布更加均匀对称。结论在给定的瓣膜设计中，使用PP和FBP组织比使用ABP和CBP组织产生更高的峰值应力。此外，确保胶原纤维沿圆周轴方向，可以降低瓣膜小叶感受到的最大应力，这也可以提高BHV的耐久性。
ObjectiveThe durability of bioprosthetic heart valve (BHV) devices, commonly made of bovine (BP) and porcine (PP) pericardium tissue, is partly limited by device calcification and tissue degeneration, which has been associated with pathological levels of mechanical stress. This study investigated the impacts of BP and PP tissues with different thicknesses and tissue mechanical properties in BHV applications.MethodsSecond Harmonic Generation (SHG) imaging was employed to visualize the collagen fibers on each side of the pericardium. Structural constitutive modeling that incorporates collagen fiber distribution obtained from multiphoton microscopy for each tissue type were derived to characterize the corresponding biaxial mechanical testing data collected in a previous study. The models were verified through finite element (FE) simulations of the biaxial test and implemented in valve closing simulations.ResultsSmooth side collagen fibers were found to correlate with the mechanical response. BHVs with adult (ABP) and calf (CBP) BP tissues had lower maximum principal stresses than those with PP and fetal (FBP) BP tissues. Collagen fiber orientation along the circumferential axis resulted in lower maximum principal stresses and more uniform and symmetric stress distributions throughout the valve.ConclusionsThe use of PP and FBP tissue resulted in higher peak stresses than ABP and CBP tissues in the given valve design. Additionally, ensuring collagen fiber orientation along the circumferential axis led to lower maximum stresses felt by the valve leaflets, which could also improve BHV durability.