Treatment of Multiple Endocrine Neoplasia 1/2 Tumors: Case Report and Review of the Literature
Treatment of Multiple Endocrine Neoplasia 1/2 Tumors: Case Report and Review of the Literature
复制标题
多发性内分泌肿瘤1/2肿瘤的治疗：病例报告及文献复习
作者：
A. Gulati;Benjamin A. Krantz;R. Moss;Wendy N Moyal;D. Tsushima;Kelley B. Mowatt;S. Schreibman;R. Fine
Background: Neuroendocrine tumors are uncommon tumors that are histopathologically and biologically heterogeneous and include the multiple endocrine neoplasia (MEN) 1 and 2 syndromes. The morbidity of MEN-1 and MEN-2 is often due to the symptomatology of the endocrine hormones produced, and the mortality mainly occurs from hepatic dysfunction incurred by liver metastases. At present, there is essentially no effective cure once the tumor has metastasized to the liver. Patient: We present a patient with progressive, metastatic MEN-1 with the classic ‘3 P’s’ triad of neuroendocrine tumor of the pancreas, parathyroid adenoma and a pituitary adenoma. Results: After progression on high-dose Sandostatin LAR (60 mg/month) and multiple surgeries, the patient had a partial response (40% decrease) to a novel regimen of capecitabine and temozolomide (CAPTEM) and progression-free survival of 18 months. He had minor grade 1 toxicities and no grade 2, 3 or 4 toxicities. Discussion: The history and treatment options for MEN-1/2 cancers are reviewed, as well as the data behind our novel regimen, CAPTEM. Conclusion: The CAPTEM regimen is a tolerable, safe, easy to administer oral regimen with possible efficacy for MEN-1 tumors.
登录
查看更多内容
影响因子：
158.5
作者：
MOERTEL, CG;LEFKOPOULO, M;KLAASSEN, D
通讯作者：
KLAASSEN, D
替莫唑胺：每天一次和两次给药对肿瘤组织 DNA 修复蛋白 O(6)-烷基鸟嘌呤-DNA-烷基转移酶水平的影响。
DOI：
--
发表时间：
2001
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Spiro,TP;Liu,L;Majka,S;Haaga,J;Willson,JK;Gerson,SL
通讯作者：
Gerson,SL
内分泌恶性肿瘤的化疗：综述。
影响因子：
4
作者：
Kvols,LK;Buck,M
通讯作者：
Buck,M
影响因子：
45.3
作者：
Chan, Jennifer A.;Stuart, Keith;Kulke, Matthew H.
通讯作者：
Kulke, Matthew H.
影响因子：
3.9
作者：
J. Hornick;Christine Frauenhoffer;Susanne M. Hooshmand;D. Ryan;P. Enzinger;J. Meyerhardt;Jeffrey W. Clark;K. Stuart;C. Fuchs;andMark S. Redston
通讯作者：
J. Hornick;Christine Frauenhoffer;Susanne M. Hooshmand;D. Ryan;P. Enzinger;J. Meyerhardt;Jeffrey W. Clark;K. Stuart;C. Fuchs;andMark S. Redston