Nanomedicine and the complement paradigm
Nanomedicine and the complement paradigm
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DOI：
10.1016/j.nano.2013.02.011
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发表时间：
2013-05-01
影响因子：
5.4
通讯作者：
Farhangrazi, Z. Shadi
中科院分区：
文献类型：
--
作者：
Moghimi, S. Moein;Farhangrazi, Z. Shadi
补体在纳米药物输注特异质反应中的作用正受到越来越多的关注。我们讨论了纳米药物的开发和可能使用补体抑制剂，以防止相关的不良反应。我们进一步呼吁启动遗传关联研究，以解开纳米药物输注相关不良反应的遗传基础，因为基因组中的大多数多态性基因属于免疫系统。(C)2013 Elsevier Inc. All rights reserved.
The role of complement in idiosyncratic reactions to nanopharmaceutical infusion is receiving increasing attention. We discuss this in relation to nanopharmaceutical development and the possible use of complement inhibitors to prevent related adverse reactions. We further call on initiation of genetic association studies to unravel the genetic basis of nanomedicine infusion-related adverse responses, since most of the polymorphic genes in the genome belong to the immune system. (C) 2013 Elsevier Inc. All rights reserved.