Roles of Education and IQ in Cognitive Reserve in Parkinson's Disease-Mild Cognitive Impairment.
Roles of Education and IQ in Cognitive Reserve in Parkinson's Disease-Mild Cognitive Impairment.
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DOI：
10.1159/000341782
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发表时间：
2012-01
影响因子：
2.3
通讯作者：
Marras C
中科院分区：
文献类型：
--
作者：
Armstrong MJ;Naglie G;Duff-Canning S;Meaney C;Gill D;Eslinger PJ;Zadikoff C;Mapstone M;Chou KL;Persad C;Litvan I;Mast BT;Fox S;Tang-Wai DF;Marras C
认知储备在帕金森病（PD）-轻度认知障碍（MCI）中的作用尚未完全了解。采用逻辑回归模型对119例连续的非痴呆PD患者进行PD-MCI、受教育年限和病前智商估计值之间的关系进行了研究。在单变量分析中，高等教育和智商与PD-MCI的几率降低相关。在多变量分析中，较高的智商与PD-MCI的几率显著降低相关，但教育程度与此无关。高智商和PD-MCI几率降低的关联支持认知储备在PD中的作用，但需要进一步研究来阐明智商和教育的相互作用以及其他因素（如就业和爱好）的影响。
The role of cognitive reserve in Parkinson's disease (PD)-mild cognitive impairment (MCI) is incompletely understood. The relationships between PD-MCI, years of education, and estimated premorbid IQ were examined in 119 consecutive non-demented PD patients using logistic regression models. Higher education and IQ were associated with reduced odds of PD-MCI in univariate analysis. In multivariable analysis, a higher IQ was associated with a significantly decreased odds of PD-MCI, but education was not. The association of higher IQ and decreased odds of PD-MCI supports a role for cognitive reserve in PD, but further studies are needed to clarify the interaction of IQ and education and the impact of other contributors such as employment and hobbies.